Gene regulation is a central topic in cell biology. Advances in omics technologies and the
accumulation of omics data have provided better opportunities for gene regulation studies …

Protein–RNA interactions are of vital importance to a variety of cellular activities. Both
experimental and computational techniques have been developed to study the interactions …

Motivation Deciphering the language of non-coding DNA is one of the fundamental
problems in genome research. Gene regulatory code is highly complex due to the existence …

Protein–DNA interactions play crucial roles in the biological systems, and identifying protein–
DNA binding sites is the first step for mechanistic understanding of various biological …

The promoter region is located near the transcription start sites and regulates transcription
initiation of the gene by controlling the binding of RNA polymerase. Thus, promoter region …

Motivation Proteases are enzymes that cleave target substrate proteins by catalyzing the
hydrolysis of peptide bonds between specific amino acids. While the functional proteolysis …

Conventional supervised binary classification algorithms have been widely applied to
address significant research questions using biological and biomedical data. This …

Promoters play a central role in controlling gene regulation; however, a small set of
promoters is used for most genetic construct design in the yeast Saccharomyces cerevisiae …

A promoter is a region in the DNA sequence that defines where the transcription of a gene
by RNA polymerase initiates, which is typically located proximal to the transcription start site …

The tremendous amount of biological sequence data available, combined with the recent
methodological breakthrough in deep learning in domains such as computer vision or …