Local cancer recurrence: the realities, challenges, and opportunities for new therapies

DA Mahvi, R Liu, MW Grinstaff… - CA: a cancer journal …, 2018 - Wiley Online Library
Locoregional recurrence negatively impacts both long‐term survival and quality of life for
several malignancies. For appropriate‐risk patients with an isolated, resectable, local …

Extracellular vesicles as an efficient and versatile system for drug delivery

XTT Dang, JM Kavishka, DX Zhang, M Pirisinu, MTN Le - Cells, 2020 - mdpi.com
Despite the recent advances in drug development, the majority of novel therapeutics have
not been successfully translated into clinical applications. One of the major factors hindering …

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1

DJ Klionsky, AK Abdel-Aziz, S Abdelfatah, M Abdellatif… - autophagy, 2021 - Taylor & Francis
In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

Surface-fill hydrogel attenuates the oncogenic signature of complex anatomical surface cancer in a single application

P Majumder, A Singh, Z Wang, K Dutta… - Nature …, 2021 - nature.com
Tumours growing in a sheet-like manner on the surface of organs and tissues with complex
topologies represent a difficult-to-treat clinical scenario. Their complete surgical resection is …

Injectable nanocomposite hydrogels improve intraperitoneal co-delivery of chemotherapeutics and immune checkpoint inhibitors for enhanced peritoneal metastasis …

S Liang, L Xiao, T Chen, P Roa, E Cocco, Z Peng… - ACS …, 2024 - ACS Publications
Intraperitoneal co-delivery of chemotherapeutic drugs (CDs) and immune checkpoint
inhibitors (ICIs) brings hope to improve treatment outcomes in patients with peritoneal …

A pure molecular drug hydrogel for post-surgical cancer treatment

Q Qian, D Wang, L Shi, Z Zhang, J Qian, J Shen, C Yu… - Biomaterials, 2021 - Elsevier
Local drug delivery systems, especially hydrogels, show superior strengths in postoperative
recurrence prevention. Despite great advances, clinical translation of the hydrogels has …

Radiolabeled biodistribution of expansile nanoparticles: Intraperitoneal administration results in tumor specific accumulation

AH Colby, J Kirsch, AN Patwa, R Liu, B Hollister… - ACS …, 2023 - ACS Publications
Nanoparticle biodistribution in vivo is an essential component to the success of nanoparticle-
based drug delivery systems. Previous studies with fluorescently labeled expansile …

Highly specific and sensitive fluorescent nanoprobes for image-guided resection of sub-millimeter peritoneal tumors

AH Colby, SM Berry, AM Moran, KA Pasion, R Liu… - ACS …, 2017 - ACS Publications
A current challenge in the treatment of peritoneal carcinomatosis is the inability to detect,
visualize, and resect small or microscopic tumors of pancreatic, ovarian, or mesothelial …

One-pot synthesis of pH-responsive hyperbranched polymer–peptide conjugates with enhanced stability and loading efficiency for combined cancer therapy

DB Cheng, PP Yang, Y Cong, FH Liu, ZY Qiao… - Polymer …, 2017 - pubs.rsc.org
Nanoparticles as drug-delivery systems have received significant attention due to their
merits such as prolonged circulation time and passive targeting of a tumor site. Polymer …

Nanoparticle drug‐delivery systems for peritoneal cancers: a case study of the design, characterization and development of the expansile nanoparticle

AH Colby, NH Oberlies, CJ Pearce… - Wiley …, 2017 - Wiley Online Library
Nanoparticle (NP)‐based drug‐delivery systems are frequently employed to improve the
intravenous administration of chemotherapy; however, few reports explore their application …