Study of the genetics of rheumatoid arthritis (RA) began about four decades ago with the
discovery of HLA-DRB1. Since the beginning of this century, a number of non-HLA risk loci …

Rheumatoid Arthritis (RA) is a chronic inflammatory disease characterized by a
heterogeneous clinical response to the different treatments. Some patients are difficult to …

Improved risk stratification and prognosis prediction in sepsis is a critical unmet need.
Clinical severity scores and available assays such as blood lactate reflect global illness …

Objective Accurate prediction of treatment responses in rheumatoid arthritis (RA) patients
can provide valuable information on effective drug selection. Anti–tumor necrosis factor (anti …

A decade after the first genome-wide association study in rheumatoid arthritis (RA), a
plethora of genetic association studies have been published on RA and its clinical or …

Psoriatic arthritis (PsA) is a complex chronic musculoskeletal condition that occurs in~ 30%
of psoriasis patients. Currently, no systematic strategy is available that utilizes the …

Immune-mediated inflammatory diseases (IMIDs), such as spondyloarthritis (SpA), psoriasis,
Crohn's disease (CD), and rheumatoid arthritis (RA) remain challenging illnesses. They …

Background Biologic therapies have revolutionized the treatment of moderate‐to‐severe
psoriasis. However, for reasons largely unknown, many patients do not respond or lose …

Making binary decisions is a common data analytical task in scientific research and
industrial applications. In data sciences, there are two related but distinct strategies …

Biologics have transformed management of inflammatory diseases. To optimize outcomes
and reduce costs, dose adjustment informed by circulating drug levels has been proposed …