The PI3K/Akt/mTOR pathway is a prototypic survival pathway that is constitutively activated
in many types of cancer. Mechanisms for pathway activation include loss of tumor …

The resistance of many types of cancer to conventional chemotherapies is a major factor
undermining successful cancer treatment. In this review, the role of a signal transduction …

The transactivation domain of the cAMP response element-binding protein (CREB) consists
of two major domains. The glutamine-rich Q2 domain, which interacts with the general …

The phosphoinositide 3‐OH kinase (PI3K)/Akt pathway has been implicated in regulating
several important cellular processes, including apoptosis, survival, proliferation, and …

Endocrine pituitary cells are neuronlike; they express numerous voltage-gated sodium,
calcium, potassium, and chloride channels and fire action potentials spontaneously …

Uterine fibroids (leiomyomas) are the most common tumors of the female reproductive tract,
occurring in up to 77% of reproductive-aged women, yet molecular pathogenesis remains …

Microdomains have been proposed to explain specificity in the myriad of possible cellular
targets of cAMP. Local differences in cAMP levels can be generated by phosphodiesterases …

RF-amide neuropeptides, with their typical Arg-Phe-NH 2 signature at their carboxyl C-
termini, belong to a lineage of peptides that spans almost the entire life tree. Throughout …

Prolactin-releasing peptide (PrRP) belongs to the large RF-amide neuropeptide family with
a conserved Arg-Phe-amide motif at the C-terminus. PrRP plays a main role in the regulation …

Background Diabetes induces central nervous system damage, leading to cognitive decline.
Fibroblast growth factor 1 (FGF1) has dual function of neuroprotection and normalizing …