A major goal of hemoglobinopathy research is to develop treatments that correct the
underlying molecular defects responsible for sickle cell disease and β-thalassemia. One …

Sickle cell disease (SCD) had first been mentioned in the literature a century ago.
Advancement in the molecular basis of the pathophysiology of the disease opens the door …

CREB is a transcription factor that functions in glucose homeostasis, growth factor-
dependent cell survival, and memory. In this study, we describe a role of CREB in human …

Although thalidomide has been shown to improve anemia in some patients with
myelodysplastic syndromes and stimulates erythropoietin in patients with multiple myeloma …

Reactivation of fetal hemoglobin (HbF) expression is an important therapeutic option in
patients with hemoglobin disorders. In sickle cell disease (SCD), an increase in HbF inhibits …

Transendothelial leukocyte migration is a major aspect of the innate immune response. It is
essential in repair and regeneration of damaged tissues and is regulated by multiple cell …

Beta-hemoglobinopathies exhibit a heterogeneous clinical picture with varying degrees of
clinical severity. Pertaining to the limited treatment options available, where blood …

The developmental regulation of γ‐globin gene expression has shaped research efforts to
establish therapeutic modalities for individuals affected with sickle cell disease (SCD). Fetal …

Abstract Hemoglobin E (HbE)/β-thalassemia is a form of β-hemoglobinopathy that is well-
known for its clinical heterogeneity. Individuals suffering from this condition are often found …

The physiological switch in expression of the embryonic, fetal, and adult β-like globin genes
has garnered enormous attention from investigators interested in transcriptional …