Review of current machine perfusion therapeutics for organ preservation

J Xu, JE Buchwald, PN Martins - Transplantation, 2020 - journals.lww.com
Because of the high demand of organs, the usage of marginal grafts has increased. These
marginal organs have a higher risk of developing ischemia-reperfusion injury, which can …

Prognostic biomarkers in kidney transplantation: a systematic review and critical appraisal

M Raynaud, S Al-Awadhi, K Louis… - Journal of the …, 2024 - journals.lww.com
Background Despite the increasing number of biomarker studies published in the transplant
literature over the past 20 years, demonstrations of their clinical benefit and their …

Kidney perfusion as an organ quality assessment tool—are we counting our chickens before they have hatched?

J De Beule, I Jochmans - Journal of Clinical Medicine, 2020 - mdpi.com
The final decision to accept an organ for transplantation remains a subjective one. With
“poor organ quality” commonly cited as a major reason for kidney discard, accurate …

Perfusate analysis during dual hypothermic oxygenated machine perfusion of liver grafts: correlations with donor factors and early outcomes

D Patrono, G Catalano, G Rizza, N Lavorato… - …, 2020 - journals.lww.com
Background. Liver graft viability assessment has long been considered a limit of
hypothermic oxygenated machine perfusion (HOPE). Aim of this study was assessing …

[HTML][HTML] Role of novel biomarkers in kidney transplantation

KJ Swanson, F Aziz, N Garg, M Mohamed… - World journal of …, 2020 - ncbi.nlm.nih.gov
Clinical application of biomarkers is an integral component of transplant care. Clinicians and
scientists alike are in search of better biomarkers than the current serologic (serum …

[HTML][HTML] Untargeted metabolomics of perfusate and their association with hypothermic machine perfusion and allograft failure

RX Liu, N Koyawala, HR Thiessen-Philbrook… - Kidney international, 2023 - Elsevier
Although hypothermic machine perfusion (HMP) is associated with improved kidney graft
viability and function, the underlying biological mechanisms are unknown. Untargeted …

Assessing kidney graft viability and its cells metabolism during machine perfusion

MI Bellini, F Tortorici, MI Amabile… - International Journal of …, 2021 - mdpi.com
Kidney transplantation is the golden treatment for end-stage renal disease. Static cold
storage is currently considered the standard method of preservation, but dynamic …

Simply adding oxygen during hypothermic machine perfusion to combat the negative effects of ischemia-reperfusion injury: fundamentals and current evidence for …

T Darius, J Nath, M Mourad - Biomedicines, 2021 - mdpi.com
The use of high-risk renal grafts for transplantation requires optimization of pretransplant
preservation and assessment strategies to improve clinical outcomes as well as to decrease …

Urinary biomarkers for diagnosis and prediction of acute kidney allograft rejection: a systematic review

F Guzzi, L Cirillo, E Buti, F Becherucci… - International Journal of …, 2020 - mdpi.com
Noninvasive tools for diagnosis or prediction of acute kidney allograft rejection have been
extensively investigated in recent years. Biochemical and molecular analyses of blood and …

[HTML][HTML] British Transplantation Society guidelines on abdominal organ transplantation from deceased donors after circulatory death

B Phillips, E Asgari, M Berry, C Callaghan… - Transplantation …, 2024 - Elsevier
Abstract The British Transplantation Society (BTS)'Guideline on transplantation from
deceased donors after circulatory death'has recently been updated and this manuscript …