Maternal-fetal immune-tolerance occurs throughout the whole gestational trimester, thus a
mother can accept a genetically distinct fetus without immunological aggressive behavior …

Common understanding suggests that the normal function of a “healthy” immune system
safe-guards and protects against the development of malignancies, whereas a genetically …

Stem cells are at the basis of tissue homeostasis, hematopoiesis and various regenerative
processes. Epigenetic changes in their somatically imprinted genes, prolonged exposure to …

Donor mesenchymal stem cells (MSCs) have been documented in fetal and maternal
circulations after plain intra-amniotic injection, with diverse therapeutic effects. We sought to …

Toleration of a semi-allogeneic fetus in the mother's uterus as well as tolerance after
allogeneic hematopoietic stem cell transplantation (HSCT) appear to share some …

Background We sought to determine the pathway through which syngeneic hematopoietic
stem cells (HSCs) delivered into the amniotic fluid can reach the fetal circulation. Methods …

Pharmaceuticals and cell-based regenerative medicine for Parkinson's disease (PD) offer
palliative relief but do not arrest the disease progression. Cell therapy has emerged as an …

Leg ulcers are a major complication of sickle cell disease (SCD). They are particularly
challenging to treat and innovative therapies are needed. We previously showed that the …

During pregnancy several types of fetal cells and fetal stem cells, including pregnancy-
associated progenitor cells (PAPCs), traffic into the maternal circulation. Whereas they also …

Fetal-maternal microchimerism describes the acquisition of fetal stem cells (FSC) by the
mother during pregnancy and their long-term persistence after parturition. FSC may engraft …