5-Lipoxygenase (5-LO) catalyzes the conversion of arachidonic acid (AA) into leukotriene
(LT) A4 and 5-hydroperoxyeicosatetraenoic acid. LTA4 can then be converted into LTB4 by …

Tea is one of the most popular beverages consumed in the world. Curcumin, the major
yellow pigment in turmeric, is used widely as a spice and food-coloring agent. In this study …

Long-standing inflammation has emerged as a hallmark of neoplastic transformation of
epithelial cells and may be a limiting factor of successful conventional tumor therapies. A …

Purpose: Previous studies have suggested an important role of aberrant arachidonic acid
metabolism, especially the cyclooxygenase (Cox) pathway, in oral carcinogenesis …

We have previously shown the importance of LTB4 in human pancreatic cancer. LTB4
receptor antagonists block growth and induce apoptosis in pancreatic cancer cells both in …

Purpose: The effects of leukotriene (LT) B4 and its receptorantagonist LY293111 on
proliferation and apoptosis of human pancreatic cancer cells were investigated, both in vitro …

Leukotriene A4 hydrolase (LTA4H) is a bifunctional zinc enzyme with the activities of
epoxide hydrolase and aminopeptidase. As an epoxide hydrolase, LTA4H catalyzes the …

Aggressive bladder cancer is a major cause of morbidity and mortality. Despite the fact that
metastatic disease results in death in the majority of bladder cancer cases, the molecular …

Ovarian cancer is the most lethal and aggressive gynecological cancer with a high
recurrence rate and is often diagnosed late. In ovarian cancer, multiple metabolic enzymes …

Fighting cancer is one of the major challenges of the 21st century. Among recently proposed
treatments, molecular-targeted therapies are attracting particular attention. The potential …