Cancer progression involves multiple genetic and epigenetic events, which involve gain-of-
functions of oncogenes and loss-of-functions of tumor suppressor genes. Classical tumor …

Statistics rate colorectal adenocarcinoma as the most common cause of cancer death on
exclusion of smoking‐related neoplasia. However, the reported accumulation of genetic …

The tumor suppressor gene CDKN2/p16/MTS1, located on chromosome 9p21, is frequently
inactivated in many human cancers through homozygous deletion. Recently, we have …

Loss-of-function mutations of retinoblastoma family (Rb) proteins drive tumorigenesis by
overcoming barriers to cellular proliferation. Consequently, factors modulating Rb function …

Sodium butyrate causes alteration of colon cancer cell morphology and biology towards that
of a more differentiated phenotype. The retinoblastoma gene encodes a nuclear …

Abnormal expression of the retinoblastoma protein (pRb) and cyclin D1 have been reported
in a variety of malignancies, but the frequencies of these deregulations and their relation to …

The retinoblastoma (Rb) gene is inactivated in a variety of human cancers, but in colorectal
carcinomas there is frequently increased expression of this gene. This is paradoxical in view …

Cyclin dependent kinases propel the cell cycle in collaboration with cyclins. We have
examined the expression of cdk2/cdc2 in adenoma and focal carcinoma in adenomatous …

Although the retinoblastoma-susceptibility gene RB1 is inactivated in a wide range of human
tumours, in colorectal cancer, the retinoblastoma protein (Rb) function is often preserved …

A reflection of the explosion of research and development in this field, this book explores
applications of omics in bioinformatics, cancer research and therapy, diabetes research …