Transcriptionally active chromatin is marked by tri-methylation of histone H3 at lysine 4
(H3K4me3) located after first exons and around transcription start sites. This epigenetic mark …

Neurodevelopmental disorders (NDDs), including intellectual disability (ID) and autism
spectrum disorders (ASD), are a large group of disorders in which early insults during brain …

Micro-electrode arrays (MEAs) are increasingly used to characterize neuronal network
activity of human induced pluripotent stem cell (hiPSC)-derived neurons. Despite their gain …

The epigenetic machinery in conjunction with the transcriptional machinery is responsible
for maintaining genome-wide chromatin states and dynamically regulating gene expression …

Germline pathogenic variants in chromatin-modifying enzymes are a common cause of
pediatric developmental disorders. These enzymes catalyze reactions that regulate …

Abstract The multidisciplinary Epigenetics and Chromatin Clinic at Johns Hopkins provides
comprehensive medical care for individuals with rare disorders that involve disrupted …

One-carbon metabolism provides the methyl groups for both DNA and histone tail
methylation reactions, two of the main epigenetic processes that tightly regulate the …

Disruption of chromatin structure due to epimutations is a leading genetic etiology of
neurodevelopmental disorders, collectively known as chromatinopathies. We show that …

Data-driven discovery of cancer driver genes, including tumor suppressor genes (TSGs) and
oncogenes (OGs), is imperative for cancer prevention, diagnosis, and treatment. Although …

Complex diseases often have distinct mechanisms spanning multiple tissues. We propose
tissue–gene fine-mapping (TGFM), which infers the posterior inclusion probability (PIP) for …