[HTML][HTML] Recent advances in design of new urease inhibitors: A review
P Kafarski, M Talma - Journal of advanced research, 2018 - Elsevier
Urease is a nickel-dependent metalloenzyme found in plants, some bacteria, and fungi.
Bacterial enzyme is of special importance since it has been demonstrated as a potent …
Bacterial enzyme is of special importance since it has been demonstrated as a potent …
[HTML][HTML] A review on the development of urease inhibitors as antimicrobial agents against pathogenic bacteria
YF Rego, MP Queiroz, TO Brito, PG Carvalho… - Journal of advanced …, 2018 - Elsevier
Ureases are enzymes that hydrolyze urea into ammonium and carbon dioxide. They have
received considerable attention due to their impacts on living organism health, since the …
received considerable attention due to their impacts on living organism health, since the …
Thiadiazole based triazole/hydrazone derivatives: Synthesis, in vitro α-glucosidase inhibitory activity and in silico molecular docking study
Thiadiazole-based hydrazide was treated with different substituted phenyl isothiocyanates
and benzaldehyde to synthesize thiadiazole-based triazole/hydrazone derivatives (4a–h & …
and benzaldehyde to synthesize thiadiazole-based triazole/hydrazone derivatives (4a–h & …
Synthesis, in vitro alpha-glucosidase inhibitory potential of benzimidazole bearing bis-Schiff bases and their molecular docking study
Voglibose and acarbose are distinguished α-glucosidase inhibitors used for controlling of
diabetes mellitus. Unfortunately, these distinguished and clinically used inhibitors have also …
diabetes mellitus. Unfortunately, these distinguished and clinically used inhibitors have also …
New oxadiazole bearing thiosemicarbazide analogues: Synthesis, anti-alzheimer inhibitory potential and their molecular docking study
Synthesized oxadiazole-bearing thiosemicarbazide analogues (1–14) were characterized
by NMR and HR-EIMS and were tested against acetylcholinesterase and …
by NMR and HR-EIMS and were tested against acetylcholinesterase and …
Synthesis, in vitro urease inhibitory potential and molecular docking study of benzofuran-based-thiazoldinone analogues
In continuation of our work on enzyme inhibition, the benzofuran-based-thiazoldinone
analogues (1–14) were synthesized, characterized by HREI-MS, 1H and 13CNMR and …
analogues (1–14) were synthesized, characterized by HREI-MS, 1H and 13CNMR and …
Design and synthesis of novel nitrothiazolacetamide conjugated to different thioquinazolinone derivatives as anti-urease agents
The present article describes the design, synthesis, in vitro urease inhibition, and in silico
molecular docking studies of a novel series of nitrothiazolacetamide conjugated to different …
molecular docking studies of a novel series of nitrothiazolacetamide conjugated to different …
Synthesis, molecular docking study of thiazole derivatives and exploring their dual inhibitor potentials against α-amylase and α-glucosidase
Diabetes mellitus is one of the most chronic metabolic diseases. The current study
comprises of evaluation of thiazole as an antidiabetic agent. A library of sixteen derivatives …
comprises of evaluation of thiazole as an antidiabetic agent. A library of sixteen derivatives …
Synthesis, in vitro urease inhibitory potential and molecular docking study of Benzimidazole analogues
Despite of many diverse biological activities exhibited by benzimidazole scaffold, it is rarely
explored for the urease inhibitory potential. For that purpose, benzimidazole analogues 1 …
explored for the urease inhibitory potential. For that purpose, benzimidazole analogues 1 …
Synthesis of bis-indolylmethanes as new potential inhibitors of β-glucuronidase and their molecular docking studies
Abstract Thirty-two (32) bis-indolylmethane-hydrazone hybrids 1–32 were synthesized and
characterized by 1 HNMR, 13 CNNMR and HREI-MS. All compounds were evaluated in vitro …
characterized by 1 HNMR, 13 CNNMR and HREI-MS. All compounds were evaluated in vitro …