Safety of nanoparticles in medicine

J Wolfram, M Zhu, Y Yang, J Shen, E Gentile… - Current drug …, 2015 - ingentaconnect.com
Nanomedicine involves the use of nanoparticles for therapeutic and diagnostic purposes.
During the past two decades, a growing number of nanomedicines have received regulatory …

Mechanical force-triggered drug delivery

Y Zhang, J Yu, HN Bomba, Y Zhu, Z Gu - Chemical reviews, 2016 - ACS Publications
Advanced drug delivery systems (DDS) enhance treatment efficacy of different therapeutics
in a dosage, spatial, and/or temporal controlled manner. To date, numerous chemical-or …

Size, shape, and flexibility influence nanoparticle transport across brain endothelium under flow

M Nowak, TD Brown, A Graham… - Bioengineering & …, 2020 - Wiley Online Library
Nanoparticle‐based therapeutic formulations are being increasingly explored for the
treatment of various ailments. Despite numerous advances, the success of nanoparticle …

[HTML][HTML] Shape effect in active targeting of nanoparticles to inflamed cerebral endothelium under static and flow conditions

A Da Silva-Candal, T Brown, V Krishnan… - Journal of Controlled …, 2019 - Elsevier
Endothelial cells represent the first biological barrier for compounds, including
nanoparticles, administered via the intravascular route. In the case of ischemic stroke and …

Assessing nanoparticle toxicity in cell-based assays: influence of cell culture parameters and optimized models for bridging the in vitro–in vivo gap

F Joris, BB Manshian, K Peynshaert… - Chemical Society …, 2013 - pubs.rsc.org
The number of newly engineered nanomaterials is vastly increasing along with their
applications. Despite the fact that there is a lot of interest and effort is being put into the …

Vascular targeting of nanocarriers: perplexing aspects of the seemingly straightforward paradigm

M Howard, BJ Zern, AC Anselmo, VV Shuvaev… - ACS …, 2014 - ACS Publications
Targeted nanomedicine holds promise to find clinical use in many medical areas.
Endothelial cells that line the luminal surface of blood vessels represent a key target for …

Polymeric nanoparticles for pulmonary protein and DNA delivery

JU Menon, P Ravikumar, A Pise, D Gyawali, CCW Hsia… - Acta biomaterialia, 2014 - Elsevier
Polymeric nanoparticles (NPs) are promising carriers of biological agents to the lung due to
advantages including biocompatibility, ease of surface modification, localized action and …

The role of biomechanical stress in extracellular vesicle formation, composition and activity

W Thompson, ET Papoutsakis - Biotechnology Advances, 2023 - Elsevier
Extracellular vesicles (EVs) are cornerstones of intercellular communication with exciting
fundamental, clinical, and more broadly biotechnological applications. However, variability …

Platelets and their biomimetics for regenerative medicine and cancer therapies

Z Li, S Hu, K Cheng - Journal of Materials Chemistry B, 2018 - pubs.rsc.org
Platelets, circulating blood cells derived from megakaryocytes, play a key role in various
physical activities, including coagulation, hemostasis, the body's innate immune response …

The role of tumor-platelet interplay and micro tumor thrombi during hematogenous tumor metastasis

Q Shi, T Ji, X Tang, W Guo - Cellular Oncology, 2023 - Springer
Background In addition to their pivotal roles in coagulation and thrombosis, platelets are
crucial in tumor progression, with plenty of clinical and experimental data demonstrating that …