During the past years, a variety of scientific and methodological developments have been
achieved, which urge chemists to increase the tools of their arsenal to improve the ease and …

Highlights•Advances in the combination of the CuAAC reaction with direct screening.•Before
library assembly, the bioisosteric potential of 1, 2, 3-triazole should be confirmed.•The …

Small-molecule synthesis usually relies on procedures that are highly customized for each
target. A broadly applicable automated process could greatly increase the accessibility of …

Terminal copper-nitrenoid complexes have inspired interest in their fundamental bonding
structures as well as their putative intermediacy in catalytic nitrene-transfer reactions. Here …

A series of novel 1, 2, 3-triazole-dithiocarbamate hybrids were designed, synthesized and
evaluated for anticancer activity against four selected human tumor cell lines (MGC-803 …

1, 5-Diarylsubstituted 1, 2, 3-triazoles are formed in high yield from aryl azides and terminal
alkynes in DMSO in the presence of catalytic tetraalkylammonium hydroxide. The reaction is …

Lysine specific demethylase 1 (LSD1), the first identified histone demethylase, plays an
important role in epigenetic regulation of gene activation and repression. The up-regulated …

Histone lysine specific demethylase 1 (LSD1) was reported to be overexpressed in several
human cancers and recognized as a promising anticancer drug target. In the current study …

Thiol-yne click chemistry is demonstrated as a modular platform for rapid and practical
fabrication of highly functional, multicomponent surfaces under ambient conditions. The …

Fluorescent bioorthogonal smart probes across the visible spectrum will enable sensitive
visualization of metabolically labeled molecules in biological systems. Here we present a …