Nuclear factor-κB (NF-κB) consists of a family of transcription factors that play critical roles in
inflammation, immunity, cell proliferation, differentiation, and survival. Inducible NF-κB …

NF-κB (nuclear factor-κB) is a collective name for inducible dimeric transcription factors
composed of members of the Rel family of DNA-binding proteins that recognize a common …

The transcription factor NF-κB has been the focus of intense investigation for nearly two
decades. Over this period, considerable progress has been made in determining the …

NF-κB signaling plays a critical role in tumor growth and treatment resistance in GBM as in
many other cancers. However, the molecular mechanisms underlying high, constitutive NF …

The Forkhead transcription factors AFX, FKHR and FKHR-L1 are orthologues of DAF-16, a
Forkhead factor that regulates longevity in Caenorhabditis elegans,,. Here we show that …

The F‐box protein Skp2 mediates c‐Myc ubiquitylation by binding to the MB2 domain.
However, the turnover of c‐Myc is largely dependent on phosphorylation of threonine‐58 …

The maintenance and preservation of distinct phases during the cell cycle is a highly
complex and coordinated process. It is regulated by phosphorylation—through the activity of …

Redox signalling in the gastrointestinal mucosa is held in an intricate balance. Potent
microbicidal mechanisms can be used by infiltrating immune cells, such as neutrophils, to …

▪ Abstract Protein degradation is deployed to modulate the steady-state abundance of
proteins and to switch cellular regulatory circuits from one state to another by abrupt …

The U box is a domain of∼ 70 amino acids that is present in proteins from yeast to humans.
The prototype U box protein, yeast Ufd2, was identified as a ubiquitin chain assembly factor …