The subject of N-acyl amino acid conjugates has been rapidly growing in recent years,
especially with regard to their analgesic and anti-inflammatory actions. The field comprises a …

High-content analysis (HCA) combines automated microscopy and automated image
analysis to quantify complex cellular anatomy and biochemistry objectively, accurately and …

Platelet-derived growth factor-BB (PDGF-BB): PDGF receptor-β (PDGFRβ) signalling in
brain pericytes is critical to the development, maintenance and function of a healthy blood …

Background and Purpose The cannabinoid receptor type 1 (CB 1) has an allosteric binding
site. The drugs ORG 27569 {5‐chloro‐3‐ethyl‐N‐[2‐[4‐(1‐piperidinyl) phenyl] ethyl]‐1H …

Synthetic cannabinoid receptor agonists (SCRAs) represent the most rapidly proliferating
class of “designer drugs” or “new psychoactive substances”. SCRAs offer unregulated …

Recreational consumption of synthetic cannabinoid receptor agonists (SCRAs) is a growing
crisis in public health in many parts of the world. AMB-FUBINACA is a member of this class …

The orphan receptor GPR18 has become a research target following the discovery of a
putative endogenous agonist, N-arachidonoyl glycine (NAGly). Chemical similarity between …

Background and purpose Arrestin or G protein bias may be desirable for novel cannabinoid
therapeutics. Arrestin‐2 and arrestin‐3 translocation to CB1 receptor have been suggested …

The most frequently reported use of medical marijuana is for pain relief. However, its
psychoactive component Δ9-tetrahydrocannabinol (THC) causes significant side effects …

Abstract Cannabinoid receptor 2 (CB2) is a GPCR highly expressed on the surface of cells
of the immune system, supporting its role in immunomodulation. This study has investigated …