Abstract Machine learning has become a pivotal tool for many projects in computational biology, bioinformatics, and health informatics. Nevertheless, beginners and biomedical …
Explainable artificial intelligence is an emerging research direction helping the user or developer of machine learning models understand why models behave the way they do …
Few studies have explored the impact of rare variants (minor allele frequency< 1%) on highly heritable plasma metabolites identified in metabolomic screens. The Finnish …
Timely identification of COVID-19 patients at high risk of mortality can significantly improve patient management and resource allocation within hospitals. This study seeks to develop …
In single-cell RNA sequencing (scRNA-seq) studies, only a small fraction of the transcripts present in each cell are sequenced. This leads to unreliable quantification of genes with low …
Multi‐omics studies promise the improved characterization of biological processes across molecular layers. However, methods for the unsupervised integration of the resulting …
Missing data is common problem faced by researchers and data scientists. Therefore, it is required to handle them appropriately in order to get better and accurate results of data …
The vast majority of coding variants are rare, and assessment of the contribution of rare variants to complex traits is hampered by low statistical power and limited functional data …
TH Pham, Y Qiu, J Zeng, L Xie, P Zhang - Nature machine intelligence, 2021 - nature.com
Phenotype-based compound screening has advantages over target-based drug discovery, but is unscalable and lacks understanding of mechanism of drug action. A chemical-induced …