The lung is the organ with the highest vascular density in the human body. It is therefore
perceivable that the endothelium of the lung contributes significantly to the circulation of …

Chronic obstructive pulmonary disease (COPD) and lung cancer, closely related to smoking,
are major lung diseases affecting millions of individuals worldwide. The generated gas …

Importance While air pollutants at historical levels have been associated with cardiovascular
and respiratory diseases, it is not known whether exposure to contemporary air pollutant …

Pulmonary MRI provides structural and quantitative functional images of the lungs without
ionizing radiation, but it has had limited clinical use due to low signal intensity from the lung …

Aging is a major risk factor for the development of chronic lung diseases such as chronic
obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF), and lung cancer …

Accumulating evidence suggests that extracellular vesicles (EVs) play a role in the
pathogenesis of lung diseases. These vesicles include exosomes, ectosomes (ie …

COPD and asthma are important chronic inflammatory disorders with a high associated
morbidity. Much research has concentrated on the role of inflammatory cells, such as the …

Background Pulmonary emphysema is divided into 3 major subtypes at autopsy:
centrilobular, paraseptal, and panlobular emphysema. These subtypes can be defined by …

Rationale: Smoking-related microvascular loss causes end-organ damage in the kidneys,
heart, and brain. Basic research suggests a similar process in the lungs, but no large studies …

Circulating endothelial microparticles (EMPs) are emerging as biomarkers of chronic
obstructive pulmonary disease (COPD) in individuals exposed to cigarette smoke (CS), but …