[HTML][HTML] Plant-derived exosome-like nanoparticles and their therapeutic activities

J Kim, S Li, S Zhang, J Wang - Asian journal of pharmaceutical sciences, 2022 - Elsevier
Nanotechnologies have been successfully applied to the treatment of various diseases.
Plant-derived exosome-like nanoparticles (PENs) are expected to become effective …

Mother's milk: a purposeful contribution to the development of the infant microbiota and immunity

K Le Doare, B Holder, A Bassett… - Frontiers in …, 2018 - frontiersin.org
Breast milk is the perfect nutrition for infants, a result of millions of years of evolution. In
addition to providing a source of nutrition, breast milk contains a diverse array of microbiota …

Milk exosomes are bioavailable and distinct microRNA cargos have unique tissue distribution patterns

S Manca, B Upadhyaya, E Mutai, AT Desaulniers… - Scientific reports, 2018 - nature.com
Exosomes participate in cell-to-cell communication, facilitated by the transfer of RNAs,
proteins and lipids from donor to recipient cells. Exosomes and their RNA cargos do not …

Maternal microbiota, early life colonization and breast milk drive immune development in the newborn

C Kalbermatter, N Fernandez Trigo… - Frontiers in …, 2021 - frontiersin.org
The innate immune system is the oldest protection strategy that is conserved across all
organisms. Although having an unspecific action, it is the first and fastest defense …

Human milk exosomes and their microRNAs survive digestion in vitro and are taken up by human intestinal cells

Y Liao, X Du, J Li, B Lönnerdal - Molecular nutrition & food …, 2017 - Wiley Online Library
Scope Human milk exosomes provide a natural means of genetic material transfer to infants;
however, the effect of gastric/pancreatic digestion milk exosomes stability and their …

Bovine milk-derived exosomes as a drug delivery vehicle for miRNA-based therapy

L del Pozo-Acebo, MC López de las Hazas… - International journal of …, 2021 - mdpi.com
MicroRNAs (miRNAs) are small non-coding RNAs with a known role as mediators of gene
expression in crucial biological processes, which converts them into high potential …

[HTML][HTML] Biological activities of extracellular vesicles and their cargos from bovine and human milk in humans and implications for infants

J Zempleni, A Aguilar-Lozano, M Sadri, S Sukreet… - The Journal of …, 2017 - Elsevier
Extracellular vesicles (EVs) in milk harbor a variety of compounds, including lipids, proteins,
noncoding RNAs, and mRNAs. Among the various classes of EVs, exosomes are of …

MicroRNAs in breastmilk and the lactating breast: potential immunoprotectors and developmental regulators for the infant and the mother

M Alsaweed, PE Hartmann, DT Geddes… - International journal of …, 2015 - mdpi.com
Human milk (HM) is the optimal source of nutrition, protection and developmental
programming for infants. It is species-specific and consists of various bioactive components …

Dietary bovine milk miRNAs transported in extracellular vesicles are partially stable during GI digestion, are bioavailable and reach target tissues but need a minimum …

MC López de las Hazas, L del Pozo-Acebo… - European Journal of …, 2022 - Springer
Abstract Purpose Extracellular RNAs are unstable and rapidly degraded unless protected.
Bovine-milk extracellular vesicles (EVs) confer protection to dietary miRNAs, although it …

[HTML][HTML] Commercial dairy cow milk microRNAs resist digestion under simulated gastrointestinal tract conditions

A Benmoussa, CHC Lee, B Laffont, P Savard… - The Journal of …, 2016 - Elsevier
Background: MicroRNAs are small, gene-regulatory noncoding RNA species present in
large amounts in milk, where they seem to be protected against degradative conditions …