Glutathione (GSH) is the most abundant antioxidant found in living organisms and has
multiple functions, most of which maintain cellular redox homeostasis. GSH preserves …

Cancer is a major health issue worldwide and the global burden of cancer is expected to
reduce the costs of treatment as well as prolong the survival time. One of the promising …

The antitumor activity of disulfiram (DSF), a traditional US Food and Drug Administration-
approved drug for the treatment of “alcohol-dependence”, is Cu2+-dependent, but the …

Background: Glioblastoma multiforme (GBM) cells are resistant to anticancer drugs. Cancer
stem cells (CSCs) are a key mediator of chemoresistance. We have reported that disulfiram …

Purpose: Glioblastoma is one of the most lethal cancers in humans, and with existing
therapy, survival remains at 14.6 months. Current barriers to successful treatment include …

To improve prognosis in recurrent glioblastoma we developed a treatment protocol based
on a combination of drugs not traditionally thought of as cytotoxic chemotherapy agents but …

Acute myeloid leukemia (AML) is a heterogeneous malignancy. Despite the advances in
past decades, the clinical outcomes of AML patients remain poor. Leukemia stem cells …

Smart responsive nanomedicines serving as carriers can take advantage of the specific
tumor microenvironment (TME) to convert non-toxic drugs into effective anticarcinogens and …

Background A folate-receptor-targeted poly (lactide-co-Glycolide)(PLGA)-Polyethylene
glycol (PEG) nanoparticle is developed for encapsulation and delivery of disulfiram into …

Cuproptosis is a newly identified form of cell death induced by excessive copper (Cu)
accumulation within cells. Mechanistically, cuproptosis results from Cu-induced aggregation …