Paracellular permeability and tight junction regulation in gut health and disease
Epithelial tight junctions define the paracellular permeability of the intestinal barrier.
Molecules can cross the tight junctions via two distinct size-selective and charge-selective …
Molecules can cross the tight junctions via two distinct size-selective and charge-selective …
Multiomics to elucidate inflammatory bowel disease risk factors and pathways
M Agrawal, KH Allin, F Petralia, JF Colombel… - Nature reviews …, 2022 - nature.com
Inflammatory bowel disease (IBD) is an immune-mediated disease of the intestinal tract, with
complex pathophysiology involving genetic, environmental, microbiome, immunological and …
complex pathophysiology involving genetic, environmental, microbiome, immunological and …
Western diets and chronic diseases
TE Adolph, H Tilg - Nature medicine, 2024 - nature.com
Abstract 'Westernization', which incorporates industrial, cultural and dietary trends, has
paralleled the rise of noncommunicable diseases across the globe. Today, the Western-style …
paralleled the rise of noncommunicable diseases across the globe. Today, the Western-style …
A unique serum IgG glycosylation signature predicts development of Crohn's disease and is associated with pathogenic antibodies to mannose glycan
J Gaifem, CS Rodrigues, F Petralia, I Alves… - Nature …, 2024 - nature.com
Inflammatory bowel disease (IBD) is characterized by chronic inflammation in the gut. There
is growing evidence in Crohn's disease (CD) of the existence of a preclinical period …
is growing evidence in Crohn's disease (CD) of the existence of a preclinical period …
Altered gut microbiome composition and function are associated with gut barrier dysfunction in healthy relatives of patients with Crohn's disease
Background & Aims The gut microbiome has been suggested to play a role in gut barrier
hemostasis, but data are scarce and limited to animal studies. We therefore aimed to assess …
hemostasis, but data are scarce and limited to animal studies. We therefore aimed to assess …
Gut microbiome composition is associated with future onset of Crohn's disease in healthy first-degree relatives
Background & Aims The cause of Crohn's disease (CD) is unknown, but the current
hypothesis is that microbial or environmental factors induce gut inflammation in genetically …
hypothesis is that microbial or environmental factors induce gut inflammation in genetically …
Deciphering the different phases of preclinical inflammatory bowel disease
JJ Rudbaek, M Agrawal, J Torres… - Nature Reviews …, 2024 - nature.com
Inflammatory bowel disease (IBD) is an immune-mediated inflammatory disease (IMID) of
the gastrointestinal tract and includes two subtypes: Crohn's disease and ulcerative colitis. It …
the gastrointestinal tract and includes two subtypes: Crohn's disease and ulcerative colitis. It …
Mucus, commensals, and the immune system
Q Zhao, CL Maynard - Gut microbes, 2022 - Taylor & Francis
The immune system in the large intestine is separated from commensal microbes and
comparatively rare enteric pathogens by a monolayer of diverse epithelial cells overlaid with …
comparatively rare enteric pathogens by a monolayer of diverse epithelial cells overlaid with …
Phage-display immunoprecipitation sequencing of the antibody epitope repertoire in inflammatory bowel disease reveals distinct antibody signatures
Inflammatory bowel diseases (IBDs), eg, Crohn's disease (CD) and ulcerative colitis (UC),
are chronic immune-mediated inflammatory diseases. A comprehensive overview of an IBD …
are chronic immune-mediated inflammatory diseases. A comprehensive overview of an IBD …
Immune response and barrier dysfunction-related proteomic signatures in preclinical phase of Crohn's disease highlight earliest events of pathogenesis
Objective The measure of serum proteome in the preclinical state of Crohn's disease (CD)
may provide insight into biological pathways involved in CD pathogenesis. We aimed to …
may provide insight into biological pathways involved in CD pathogenesis. We aimed to …