The kidney maintains electrolyte, water, and acid-base balance, eliminates foreign and
waste compounds, regulates blood pressure, and secretes hormones. There are at least 16 …

Uromodulin (also known as Tamm-Horsfall protein) is exclusively produced in the kidney
and is the most abundant protein in normal urine. The function of uromodulin remains …

Chronic kidney disease (CKD) is responsible for a public health burden with multi-systemic
complications. Through trans-ancestry meta-analysis of genome-wide association studies of …

Uromodulin, a protein exclusively produced by the kidney, is the most abundant urinary
protein in physiological conditions. Already described several decades ago, uromodulin has …

Expression quantitative trait loci (eQTL) studies illuminate the genetics of gene expression
and, in disease research, can be particularly illuminating when using the tissues directly …

Uromodulin, released from tubular cells of the ascending limb into the blood, may be
associated with kidney function. This work studies the relevance of plasma uromodulin as a …

The thick ascending limb occupies a central anatomic and functional position in human
renal physiology, with critical roles in the defense of the extracellular fluid volume, the …

Background Urinary extracellular vesicles (uEVs) are a promising source for biomarker
discovery, but optimal approaches for normalization, quantification, and characterization in …

Autosomal dominant tubulointerstitial kidney disease (ADTKD) is an increasingly recognized
cause of end-stage kidney disease, primarily due to mutations in UMOD and MUC1. The …

Background An ELISA to analyse uromodulin in human serum (sUmod) was developed,
validated and tested for clinical applications. Methods We assessed sUmod, a very stable …