Perfluorinated and polyfluorinated compounds (PFASs) are a class of synthetic chemical
substances that are widely used in human production and life, such as fire-fighting foams …

Niches are local tissue microenvironments that maintain and regulate stem cells.
Haematopoiesis provides a model for understanding mammalian stem cells and their …

Background Extracellular matrix (ECM) is a dynamic and complex environment
characterized by biophysical, mechanical and biochemical properties specific for each …

The bone marrow niche has mystified scientists for many years, leading to widespread
investigation to shed light into its molecular and cellular composition. Considerable efforts …

The presence of disseminated tumour cells (DTCs) in bone marrow is predictive of poor
metastasis-free survival of patients with breast cancer with localized disease. DTCs persist …

Apart from sharing common ancestry with chordates, sea cucumbers exhibit a unique
morphology and exceptional regenerative capacity. Here we present the complete genome …

Abstract Sphingosine-1-phosphate (S1P), a potent signalling lipid secreted by red blood
cells and platelets,, plays numerous biologically significant roles,,,. However, the identity of …

Bone vasculature and bone marrow vascular niches supply oxygen, nutrients, and secrete
angiocrine factors required for the survival, maintenance, and self‐renewal of stem and …

Fibroblastic stromal cells are as diverse, in origin and function, as the niches they fashion in
the mammalian body. This cellular variety impacts the spectrum of responses elicited by the …

Tissue homeostasis requires the presence of multipotent adult stem cells that are capable of
efficient self-renewal and differentiation; some of these have been shown to exist in a …