The yeast Saccharomyces cerevisiae has been used to develop a wide range of highly
tractable living models of the major human neurodegenerative diseases. Yet even though …

Mutations in the p53 tumor suppressor are frequent causes of cancer. Because p53
aggregates appear in some tumor cells, it has been suggested that p53 could also cause …

Mutations in adenine biosynthesis pathway genes ADE1 and ADE2 have been
conventionally used to score for prion [PSI+] in yeast. If ade1‐14 mutant allele is present …

Pichia pastoris is widely used as a host system for heterologous protein expression in both
academia and industry. Production is typically accomplished by a fed-batch induction …

The single-celled baker's yeast, Saccharomyces cerevisiae, can sustain a number of
amyloid-based prions, the three most prominent examples being [URE3],[PSI+], and [PIN+] …

The yeast Saccharomyces cerevisiae is a tractable model organism in which both to explore
the molecular mechanisms underlying the generation of disease-associated protein …

Huntington's disease (HD) is a genetic disorder caused by a CAG expansion mutation in the
huntingtin gene leading to polyglutamine (polyQ) expansion in the N-terminal part of …

abstract The year 2015 sees the fiftieth anniversary of the publication of a research paper
that underpins much of our understanding of fungal prion biology, namely “ψ, a cytoplasmic …

Quality control mechanisms promote aggregation and degradation of misfolded proteins. In
budding yeast, the human von Hippel–Lindau protein (pVHL, officially known as VHL) is …

Protein aggregation is both a hallmark of and a driving force for a number of diseases. It is
therefore important to identify the nature of these aggregates and the mechanism (s) by …