Acute respiratory distress syndrome in adults: diagnosis, outcomes, long-term sequelae, and management

EA Gorman, CM O'Kane, DF McAuley - The Lancet, 2022 - thelancet.com
Acute respiratory distress syndrome (ARDS) is characterised by acute hypoxaemic
respiratory failure with bilateral infiltrates on chest imaging, which is not fully explained by …

Lung endothelium, tau, and amyloids in health and disease

R Balczon, MT Lin, S Voth, AR Nelson… - Physiological …, 2024 - journals.physiology.org
Lung endothelia in the arteries, capillaries, and veins are heterogeneous in structure and
function. Lung capillaries in particular represent a unique vascular niche, with a thin yet …

Opportunities for improved clinical trial designs in acute respiratory distress syndrome

KD Wick, NR Aggarwal, MAQ Curley… - The Lancet …, 2022 - thelancet.com
The acute respiratory distress syndrome (ARDS) is a common critical illness syndrome with
high morbidity and mortality. There are no proven pharmacological therapies for ARDS. The …

Endothelial dysfunction triggers acute respiratory distress syndrome in patients with sepsis: a narrative review

R Cusack, LD Bos, P Povoa, I Martin-Loeches - Frontiers in Medicine, 2023 - frontiersin.org
Acute respiratory distress syndrome (ARDS) is a severe organ failure occurring mainly in
critically ill patients as a result of different types of insults such as sepsis, trauma or …

Advancing precision medicine for the diagnosis and treatment of acute respiratory distress syndrome

AN Rizzo, NR Aggarwal, BT Thompson… - Journal of Clinical …, 2023 - mdpi.com
Acute respiratory distress syndrome (ARDS) is a common and life-threatening cause of
respiratory failure. Despite decades of research, there are no effective pharmacologic …

Towards a biological definition of ARDS: are treatable traits the solution?

LDJ Bos, JG Laffey, LB Ware, NFL Heijnen… - Intensive care medicine …, 2022 - Springer
The pathophysiology of acute respiratory distress syndrome (ARDS) includes the
accumulation of protein-rich pulmonary edema in the air spaces and interstitial areas of the …

[HTML][HTML] Alveolar epithelial glycocalyx degradation mediates surfactant dysfunction and contributes to acute respiratory distress syndrome

AN Rizzo, SM Haeger, K Oshima, Y Yang… - JCI insight, 2022 - ncbi.nlm.nih.gov
Acute respiratory distress syndrome (ARDS) is a common cause of respiratory failure yet has
few pharmacologic therapies, reflecting the mechanistic heterogeneity of lung injury. We …

[HTML][HTML] Glucocorticoid therapy for acute respiratory distress syndrome: Current concepts

Y Zhao, Z Yao, S Xu, L Yao, Z Yu - Journal of Intensive Medicine, 2024 - Elsevier
Acute respiratory distress syndrome (ARDS), a fatal critical disease, is induced by various
insults. ARDS represents a major global public health burden, and the management of …

Bacterial pneumonia-induced shedding of epithelial heparan sulfate inhibits the bactericidal activity of cathelicidin in a murine model

EP Zehr, CL Erzen, K Oshima… - … of Physiology-Lung …, 2024 - journals.physiology.org
Bacterial pneumonia is a common clinical syndrome leading to significant morbidity and
mortality worldwide. In the current study, we investigate a novel, multidirectional relationship …

Research Bronchoscopy Standards and the Need for Noninvasive Sampling of the Failing Lungs

W Bain, JA Bastarache, A Sarma… - Annals of the …, 2024 - atsjournals.org
To the Editor: We read with great interest the Official American Thoracic Society Workshop
Report: Research Bronchoscopies in Critically Ill Research Participants (1) that outlined …