Mitochondria as a cellular hub in infection and inflammation
Mitochondria are the energy center of the cell. They are found in the cell cytoplasm as
dynamic networks where they adapt energy production based on the cell's needs. They are …
dynamic networks where they adapt energy production based on the cell's needs. They are …
ROS and diseases: Role in metabolism and energy supply
S Yang, G Lian - Molecular and cellular biochemistry, 2020 - Springer
Researches dedicated to reactive oxygen species (ROS) had been performed for decades,
yet the outcomes remain controversial. With the relentless effort of studies, researchers have …
yet the outcomes remain controversial. With the relentless effort of studies, researchers have …
[HTML][HTML] Immunity and vaccine development efforts against Trypanosoma cruzi
Trypanosoma cruzi (T. cruzi) is the causative agent for Chagas disease (CD). There is a
critical lack of methods for prevention of infection or treatment of acute infection and chronic …
critical lack of methods for prevention of infection or treatment of acute infection and chronic …
Mapping of host-parasite-microbiome interactions reveals metabolic determinants of tropism and tolerance in Chagas disease
Chagas disease (CD) is a parasitic disease caused by Trypanosoma cruzi protozoa,
presenting with cardiomyopathy, megaesophagus, and/or megacolon. To determine the …
presenting with cardiomyopathy, megaesophagus, and/or megacolon. To determine the …
IL-10/STAT3/SOCS3 axis is involved in the anti-inflammatory effect of benznidazole
Anti-parasitic treatment for Chagas disease mainly relies on benznidazole, which is virtually
the only drug available in the market. Besides its anti-parasitic effects, benznidazole has anti …
the only drug available in the market. Besides its anti-parasitic effects, benznidazole has anti …
Disease Tolerance and Pathogen Resistance Genes May Underlie Trypanosoma cruzi Persistence and Differential Progression to Chagas Disease Cardiomyopathy
Chagas disease is caused by infection with the protozoan Trypanosoma cruzi and affects
over 8 million people worldwide. In spite of a powerful innate and adaptive immune …
over 8 million people worldwide. In spite of a powerful innate and adaptive immune …
Dual and opposite roles of reactive oxygen species (ROS) in Chagas disease: beneficial on the pathogen and harmful on the host
Chagas disease is a neglected tropical disease, which affects an estimate of 6‐7 million
people worldwide. Chagas disease is caused by Trypanosoma cruzi, which is a eukaryotic …
people worldwide. Chagas disease is caused by Trypanosoma cruzi, which is a eukaryotic …
DNA damage and oxidative stress in human cells infected by Trypanosoma cruzi
PTV Florentino, D Mendes, FNL Vitorino… - PLoS …, 2021 - journals.plos.org
Trypanosoma cruzi is the etiologic agent of Chagas' disease. Infected cells with T. cruzi
activate several responses that promote unbalance of reactive oxygen species (ROS) that …
activate several responses that promote unbalance of reactive oxygen species (ROS) that …
Selenium as an interesting option for the treatment of Chagas disease: A review
V Alcolea, S Pérez-Silanes - European journal of medicinal chemistry, 2020 - Elsevier
Chagas disease is one of the most prevalent tropical neglected diseases and causes high
mortality and morbidity in endemic countries. Current treatments for this disease, nifurtimox …
mortality and morbidity in endemic countries. Current treatments for this disease, nifurtimox …
Dihydromyricetin ameliorates cardiac ischemia/reperfusion injury through Sirt3 activation
L Wei, X Sun, X Qi, Y Zhang, Y Li… - BioMed Research …, 2019 - Wiley Online Library
During myocardial infarction, quickly opening the occluded coronary artery is a major
method to save the ischemic myocardium. However, it also induces reperfusion injury …
method to save the ischemic myocardium. However, it also induces reperfusion injury …