Long QT and short QT syndromes (LQTS and SQTS) are cardiac repolarization
abnormalities that are characterized by length perturbations of the QT interval as measured …

A variety of inherited human disorders affecting skeletal muscle contraction, heart rhythm,
and nervous system function have been traced to mutations in genes encoding voltage …

Sick sinus syndrome (SSS) describes an arrhythmia phenotype attributed to sinus node
dysfunction and diagnosed by electrocardiographic demonstration of sinus bradycardia or …

Background—Congenital long-QT syndrome (LQTS) is potentially lethal secondary to
malignant ventricular arrhythmias and is caused predominantly by mutations in genes that …

Cardiac sodium channel are protein complexes that are expressed in the sarcolemma of
cardiomyocytes to carry a large inward depolarizing current (I Na) during phase 0 of the …

Most cardiologists who care for adults have no or minimal experience with
electrocardiograms (ECGs) recorded in infants. So far, this has had no practical implications …

Atrial standstill (AS) is a rare arrhythmia that occasionally appears to be genetically
determined. This study investigates the genetic background of this arrhythmogenic disorder …

Cardiac conduction defects associate with mutations in SCN5A, the gene encoding the
cardiac Na+ channel. In the present study, we characterized a family in which the proband …

The National Heart, Lung, and Blood Institute and Office of Rare Diseases at the National
Institutes of Health organized a workshop (September 14 to 15, 2006, in Bethesda, Md) to …

Cardiac sodium channel dysfunction caused by mutations in the SCN5A gene is associated
with a number of relatively uncommon arrhythmia syndromes, including long-QT syndrome …