Many human malignancies are associated with aberrant regulation of protein or lipid
kinases due to mutations, chromosomal rearrangements and/or gene amplification. Protein …

The p38 mitogen-activated protein kinase (p38MAPK, termed here p38) cascade is a central
signaling pathway that transmits stress and other signals to various intracellular targets in …

The inhibition of kinases has been pursued by the pharmaceutical industry for over 20 years.
While the locations of the sites that bind type II and III inhibitors at or near the adenosine 5 …

Genetic and other variations frequently affect protein functions. Scientific articles can contain
confusing descriptions about which function or property is affected, and in many cases the …

Transcription factor phosphorylation at specific sites often activates gene expression, but
how environmental cues quantitatively control transcription is not well-understood. Activating …

The master regulatory transcription factor GATA-2 triggers hematopoietic stem and
progenitor cell generation. GATA2 haploinsufficiency is implicated in myelodysplastic …

Essential functions of mitogen-activated protein kinases (MAPKs) depend on their capacity
to selectively phosphorylate a limited repertoire of substrates. MAPKs harbor a conserved …

The p38 MAPK family is composed of four kinases of which p38α/MAPK14 is the major
proinflammatory member. These kinases contribute to many inflammatory diseases, but the …

Constitutive activation of the extracellular-signal-regulated kinases 1 and 2 (ERK1/2) are
central to regulating the proliferation and survival of many cancer cells. The current inhibitors …

Five SOX peptides are used to classify the MAPK groups and isoforms thereof using
chemometrics. The score plots show excellent classification and accuracy, while support …