Role of lipid accumulation and inflammation in atherosclerosis: focus on molecular and cellular mechanisms

K Malekmohammad, EE Bezsonov… - Frontiers in …, 2021 - frontiersin.org
Atherosclerosis is a chronic lipid-driven and maladaptive inflammatory disease of arterial
intima. It is characterized by the dysfunction of lipid homeostasis and signaling pathways …

Pathophysiology of cardiovascular diseases: new insights into molecular mechanisms of atherosclerosis, arterial hypertension, and coronary artery disease

W Frąk, A Wojtasińska, W Lisińska, E Młynarska… - Biomedicines, 2022 - mdpi.com
Cardiovascular diseases (CVDs) are disorders associated with the heart and circulatory
system. Atherosclerosis is its major underlying cause. CVDs are chronic and can remain …

Mitochondrial dysfunction in vascular endothelial cells and its role in atherosclerosis

K Qu, F Yan, X Qin, K Zhang, W He, M Dong… - Frontiers in …, 2022 - frontiersin.org
The mitochondria are essential organelles that generate large amounts of ATP via the
electron transport chain (ECT). Mitochondrial dysfunction causes reactive oxygen species …

Prospective roles of tumor necrosis factor-alpha (TNF-α) in COVID-19: prognosis, therapeutic and management

Z Mohd Zawawi, J Kalyanasundram… - International journal of …, 2023 - mdpi.com
The coronavirus disease 2019 (COVID-19) became a worldwide concern at the beginning of
2020 and has affected millions. Several previous studies revealed the impact of the …

Fusobacterium nucleatum and its associated systemic diseases: epidemiologic studies and possible mechanisms

Z Fan, P Tang, C Li, Q Yang, Y Xu, C Su… - Journal of Oral …, 2023 - Taylor & Francis
Background Fusobacterium nucleatum (F. nucleatum) is an anaerobic oral commensal and
the major coaggregation bridge organism linking early and late colonisers. In recent years, a …

The crosstalk between Nrf2 and NF-κB pathways in coronary artery disease: Can it be regulated by SIRT6?

E Casper - Life sciences, 2023 - Elsevier
Coronary artery disease (CAD) is the leading cause of death worldwide. Oxidative stress
and inflammation are major mechanisms responsible for the progression of CAD. Nuclear …

Human gut microbiota in coronary artery disease: a systematic review and meta-analysis

M Choroszy, K Litwinowicz, R Bednarz, T Roleder… - Metabolites, 2022 - mdpi.com
In recent years, the importance of the gut microbiome in human health and disease has
increased. Growing evidence suggests that gut dysbiosis might be a crucial risk factor for …

[HTML][HTML] Phytoconstituents as modulators of NF-κB signalling: Investigating therapeutic potential for diabetic wound healing

JP Yadav, A Verma, P Pathak, AR Dwivedi… - Biomedicine & …, 2024 - Elsevier
The NF-κB pathway plays a pivotal role in impeding the diabetic wound healing process,
contributing to prolonged inflammation, diminished angiogenesis, and reduced proliferation …

Conceptual design and analysis of novel hybrid auxetic stents with superior expansion

AMM Zamani, E Etemadi, M Bodaghi, H Hu - Mechanics of Materials, 2023 - Elsevier
This paper presents a conceptual design and finite element (FE) simulation of a novel class
of negative Poisson's ratio (NPR) stents with hybrid auxetic structures fabricated by FDM 3D …

Endothelial dysfunction: Molecular mechanisms and clinical implications

X Wang, B He - MedComm, 2024 - Wiley Online Library
Cardiovascular disease (CVD) and its complications are a leading cause of death
worldwide. Endothelial dysfunction plays a crucial role in the initiation and progression of …