Isolation and characterization of extracellular vesicle subpopulations from tissues

R Crescitelli, C Lässer, J Lötvall - Nature protocols, 2021 - nature.com
Extracellular vesicles (EVs) are lipid bilayered membrane structures released by all cells.
Most EV studies have been performed by using cell lines or body fluids, but the number of …

Tissue‐derived extracellular vesicles in cancers and non‐cancer diseases: present and future

SR Li, QW Man, X Gao, H Lin, J Wang… - Journal of …, 2021 - Wiley Online Library
Extracellular vesicles (EVs) are lipid‐bilayer membrane structures secreted by most cell
types. EVs act as messengers via the horizontal transfer of lipids, proteins, and nucleic …

Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches

JA Welsh, DCI Goberdhan, L O'Driscoll… - Journal of …, 2024 - Wiley Online Library
Extracellular vesicles (EVs), through their complex cargo, can reflect the state of their cell of
origin and change the functions and phenotypes of other cells. These features indicate …

[HTML][HTML] Mesenchymal stem cell-derived extracellular vesicles ameliorate Alzheimer's disease-like phenotypes in a preclinical mouse model

AS Cone, X Yuan, L Sun, LC Duke, MP Vreones… - Theranostics, 2021 - ncbi.nlm.nih.gov
Alzheimer's disease (AD) is an irreversible neurodegenerative disorder that affects more
than 44 million people worldwide. Despite the high disease burden, there is no effective …

Engineering extracellular vesicles by three‐dimensional dynamic culture of human mesenchymal stem cells

X Yuan, L Sun, R Jeske, D Nkosi… - Journal of …, 2022 - Wiley Online Library
Human mesenchymal stem cell (hMSC) derived extracellular vesicles (EVs) have shown
therapeutic potential in recent studies. However, the corresponding therapeutic components …

Upscaling human mesenchymal stromal cell production in a novel vertical-wheel bioreactor enhances extracellular vesicle secretion and cargo profile

R Jeske, C Liu, L Duke, MLC Castro, L Muok, P Arthur… - Bioactive Materials, 2023 - Elsevier
Human mesenchymal stromal cells (hMSCs) are mechanically sensitive undergoing
phenotypic alterations when subjected to shear stress, cell aggregation, and substrate …

Proteomic and biological profiling of extracellular vesicles from Alzheimer's disease human brain tissues

S Muraoka, AM DeLeo, MK Sethi… - Alzheimer's & …, 2020 - Wiley Online Library
Abstract Introduction Extracellular vesicles (EVs) from human Alzheimer's disease (AD)
biospecimens contain amyloid beta (Aβ) peptide and tau. While AD EVs are known to affect …

Extracellular vesicles and intercellular communication in the central nervous system

LR Lizarraga‐Valderrama, GK Sheridan - FEBS letters, 2021 - Wiley Online Library
Neurons and glial cells of the central nervous system (CNS) release extracellular vesicles
(EVs) to the interstitial fluid of the brain and spinal cord parenchyma. EVs contain proteins …

Influence of species and processing parameters on recovery and content of brain tissue-derived extracellular vesicles

Y Huang, L Cheng, A Turchinovich… - Journal of …, 2020 - Taylor & Francis
Extracellular vesicles (EVs) are involved in a wide range of physiological and pathological
processes by shuttling material out of and between cells. Tissue EVs may thus lend insights …

[HTML][HTML] Extracellular Vesicles in neural cell interaction and CNS homeostasis

A Schnatz, C Müller, A Brahmer… - FASEB …, 2021 - ncbi.nlm.nih.gov
Central nervous system (CNS) homeostasis critically depends on the interaction between
neurons and glia cells. Extracellular vesicles (EVs) recently emerged as versatile …