Detection of cancer at an early stage when it is still localized improves patient response to
medical interventions for most cancer types. The success of screening tools such as cervical …

Brain metastases are a serious obstacle in the treatment of patients with solid tumors and
contribute to the morbidity and mortality of these cancers. It is speculated that the frequency …

Senescent cells (SCs) have been considered a source of age-related chronic sterile
systemic inflammation and a target for anti-aging therapies. To understand mechanisms …

Liver metastasis is a major cause of mortality for patients with colorectal cancer (CRC).
Mismatch repair–proficient (pMMR) CRCs make up about 95% of metastatic CRCs, and are …

The past decade has seen dramatic technological advances in the field of optical coherence
tomography (OCT) imaging. These advances have driven commercialization and clinical …

Despite being widely used in reporter technologies, bioluminescent systems are largely
understudied. Of at least forty different bioluminescent systems thought to exist in nature …

Despite tremendous efforts worldwide from clinicians and cancer scientists, pancreatic
ductal adenocarcinoma (PDA) remains a deadly disease for which no cure is available …

Medulloblastoma is the most common pediatric malignant brain tumor. Although current
therapies improve survival, these regimens are highly toxic and are associated with …

Current anti-VEGF therapies for colorectal cancer (CRC) provide limited survival benefit, as
tumors rapidly develop resistance to these agents. Here, we have uncovered an …

The survival benefit of anti–vascular endothelial growth factor (VEGF) therapy in metastatic
colorectal cancer (mCRC) patients is limited to a few months because of acquired …