Significant progress has been made in understanding the pre-symptomatic phase of
amyotrophic lateral sclerosis. While much is still unknown, advances in other …

This article focuses on clinical applications of arterial spin labeling (ASL) and is part of a
wider effort from the International Society for Magnetic Resonance in Medicine (ISMRM) …

Cerebral small vessel disease (SVD) is characterized by changes in the pial and
parenchymal microcirculations. SVD produces reductions in cerebral blood flow and …

Arterial spin labeling (ASL) has undergone significant development since its inception, with
a focus on improving standardization and reproducibility of its acquisition and quantification …

Could nose-to-brain pathways mediate the effects of peptides such as oxytocin (OT) on brain
physiology when delivered intranasally? We address this question by contrasting two …

A summit held March 2023 in Scottsdale, Arizona (USA) focused on the intronic
hexanucleotide expansion in the C9ORF72 gene and its relevance in frontotemporal …

Aims Neurovascular-glymphatic dysfunction plays an important role in Alzheimer's disease
and has been analysed mainly in relation to amyloid-beta (Aβ) pathology. Here, we aim to …

Importance During a time with the potential for novel treatment strategies, early detection of
disease manifestations at an individual level in presymptomatic carriers of a hexanucleotide …

Background A mutation in C9orf72 constitute a cross-link between amyotrophic lateral
sclerosis (ALS) and fronto-temporal dementia (FTD). At clinical manifestation, both patient …

Cognitive impairment associated with vascular etiology has been of considerable interest in
the development of dementia. Recent studies have started to uncover cerebral blood flow …