Fat induces glucose metabolism in nontransformed liver cells and promotes liver tumorigenesis

LA Broadfield, JAG Duarte, R Schmieder, D Broekaert… - Cancer research, 2021 - AACR
Hepatic fat accumulation is associated with diabetes and hepatocellular carcinoma (HCC).
Here, we characterize the metabolic response that high-fat availability elicits in livers before …

Comprehensive analysis of differences of N6-methyladenosine RNA methylomes between high-fat-fed and normal mouse livers

Z Luo, Z Zhang, L Tai, L Zhang, Z Sun, L Zhou - Epigenomics, 2019 - Taylor & Francis
Aim: To assess the m6A methylome in mouse fatty liver induced by a high-fat diet (HFD).
Materials & methods: MeRIP-seq was performed to identify differences in the m6A …

Gene expression modulation of lipid and central energetic metabolism related genes by high-fat diet intake in the main homeostatic tissues

B Reynés, M Palou, A Palou - Food & function, 2017 - pubs.rsc.org
It is generally assumed that high-fat (HF) diets induce characteristic gene expression
regulation, which may cause metabolic alterations associated with an increased risk of …

β-fructofuranosidase regulation in silkworm silk gland development: Implications for silk gland morphogenesis and silk production

B Sun, H Zhang, C Chen, J Yan, J Hong, J Xu… - International Journal of …, 2025 - Elsevier
This study investigates the impact of β-fructofuranosidase (Bmsuc1) on the development of
the silk gland in silkworms (Bombyx mori). Previous research shows that Bmsuc1 is highly …

Maternal consumption of a cafeteria diet during lactation in rats leads the offspring to a thin-outside-fat-inside phenotype

CA Pomar, R Van Nes, J Sánchez, C Picó… - International Journal of …, 2017 - nature.com
Methods: Nursing rats were fed a control diet or a cafeteria diet during lactation. Milk was
obtained at different time points of lactation. Offspring (males and females) were weaned …

Cognitive impairment in metabolically-obese, normal-weight rats: identification of early biomarkers in peripheral blood mononuclear cells

M Cifre, A Palou, P Oliver - Molecular neurodegeneration, 2018 - Springer
Background Metabolically-obese, normal-weight (MONW) individuals are not obese in terms
of weight and height but have a number of obesity-related features (eg greater visceral …

Proteomic analyses of cysteine redox in high-fat-fed and fasted mouse livers: implications for liver metabolic homeostasis

Y Li, Z Luo, X Wu, J Zhu, K Yu, Y Jin… - Journal of proteome …, 2018 - ACS Publications
Intensive oxidative stress occurs during high-fat-diet-induced hepatic fat deposition,
suggesting a critical role for redox signaling in liver metabolism. Intriguingly, evidence …

Cpt1a gene expression in peripheral blood mononuclear cells as an early biomarker of diet-related metabolic alterations

R Díaz-Rúa, A Palou, P Oliver - Food & nutrition research, 2016 - Taylor & Francis
Background Research on biomarkers that provide early information about the development
of future metabolic alterations is an emerging discipline. Gene expression analysis in …

Perinatal Treatment with Leptin, but Not Celastrol, Protects from Metabolically Obese, Normal-Weight Phenotype in Rats

B Reynés, M Cifre, A Palou, P Oliver - Nutrients, 2022 - mdpi.com
Perinatal nutrition has a well-known influence on obesity susceptibility. We previously
demonstrated the protective anti-obesity effects of perinatal leptin administration. Celastrol is …

Dietary supplementation of defatted kenaf (Hibiscus cannabinus L.) seed meal and its phenolics–saponins rich extract effectively attenuates diet-induced …

KW Chan, M Ismail, NM Esa, MU Imam, DJ Ooi… - Food & function, 2018 - pubs.rsc.org
Kenaf is one of the important commercial fiber crops worldwide and defatted kenaf seed
meal (DKSM) is a secondary by-product from the kenaf industry. Thus, efforts to turn this low …