Abstract Type 2 diabetes (T2D), cardiovascular disease (CVD) and chronic kidney disease
(CKD), are recognized among the most disruptive public health issues of the current century …

The dysregulation of the β-cell functional mass, which is a reduction in the number of β-cells
and their ability to secure adequate insulin secretion, represents a key mechanistic factor …

Westernized populations are plagued by a plethora of chronic non-infectious degenerative
diseases, termed as “civilization diseases”, like obesity, diabetes, cardiovascular diseases …

Non-communicable diseases, like diabetes, cardiovascular diseases, cancer, stroke, chronic
obstructive pulmonary disease, osteoporosis, arthritis, Alzheimer's disease and other more …

The renin-angiotensin (Ang) system (RAS) is a complex hormonal system present locally in
several tissues such as cardiovascular organs. RAS deregulation through overactivation of …

Sepsis, as life-threatening organ dysfunction caused by a dysregulated host response to
infection, is characterized by the extensive release of cytokines and other mediators. Sini …

Abstract The Renin Angiotensin System (RAS), a key regulator of blood pressure has been
linked to metabolic disorders. We have previously reported that adipose overexpression of …

Type 2 diabetes is often complicated with hypertension, such that 73.6% of patients≥ 18
years with type 2 diabetes also have hypertension. With increasing age, the risk of …

Summary Disruption of calcium (Ca 2+) homeostasis in neurons is a hallmark of
neurodegenerative diseases. Here, we investigate the mechanisms leading to Ca 2+ …

Expression of angiotensin II (Ang II), a key biological peptide in the renin‑angiotensin
system, is closely associated with the occurrence and development of cancer. Ang II binds …