Background Critically ill patients diagnosed with COVID-19 may develop a pro-thrombotic
state that places them at a dramatically increased lethal risk. Although platelet activation is …

Highlights•Antiplatelet agents play a key role in the therapy of acute coronary syndromes
(ACS).•P2Y 12 antagonists inhibit processes important for both thrombosis and …

Background: Platelets from patients with diabetes mellitus are hyperactive. Hyperactivated
platelets may contribute to cardiovascular complications and inadequate responses to …

P2Y 12 receptor is a 342 amino acid Gi-coupled receptor predominantly expressed on
platelets. P2Y 12 receptor is physiologically activated by ADP and inhibits adenyl cyclase …

Cardiovascular disease is the leading cause of global mortality, with anticoagulant therapy
being the main prevention and treatment strategy. Recombinant hirudin (r-hirudin) is a direct …

Salviae miltiorrhiza (Danshen) has been used for thousands of years in China and some
other Asian countries to treat atherothrombotic diseases. Salvianolate which consists of …

Citrus flavanoids intake can reduce the risk of cardiovascular diseases. Naringenin, a
natural predominant flavonoid abundant in citrus fruits, possesses protective effects against …

Abstract Background and Purpose Previously, we discovered that the activation of
nucleotide-binding oligomerization domain 2 (NOD2) enhances platelet activation. We here …

Aberrant platelet activation plays a critical role in the pathogenesis of heart attack and
stroke. dl-3-n-butylphthalide (NBP) has been approved in China to treat stroke with multiple …

Background Classical anticoagulants and antiplatelets are associated with high frequencies
of bleeding complications or treatment failure when used as single agents. Thrombin plays …