Foxp3-expressing CD4+ regulatory T (Treg) cells play key roles in the prevention of
autoimmunity and the maintenance of immune homeostasis and represent a major barrier to …

Abstract Development of a comprehensive regulatory T (T reg) cell compartment in the
thymus is required to maintain immune homeostasis and prevent autoimmunity. In this study …

Most T lymphocytes, including regulatory T cells (Treg cells), differentiate in the thymus. The
age-dependent involution of this organ leads to decreasing production of T cells. Here we …

The manner in which regulatory T cells (Treg cells) control lymphocyte homeostasis is not
fully understood. We identified two Treg cell populations with differing degrees of self …

Foxp3+ regulatory T cells (Treg) maintain the integrity of the organism by preventing
excessive immune responses. These cells protect against autoimmune diseases but are …

Thymic epithelial cells (TECs) and hematopoietic antigen presenting cells (HAPCs) in the
thymus microenvironment provide essential signals to self-reactive thymocytes that induce …

Regulatory T cells (Treg) are critical players of immune tolerance that develop in the thymus
via two distinct developmental pathways involving CD25+ Foxp3− and CD25− Foxp3lo …

Current models of Foxp3+ regulatory T cell (Treg) development involve CCR7-mediated
migration of thymocytes into the thymus medulla to enable essential interactions with …

Foxp3+ regulatory T cells (Tregs) are potent suppressor cells, essential for the maintenance
of immune homeostasis. Most Tregs develop in the thymus and are then released into the …

The development of T‐cell self‐tolerance in the thymus is important for establishing immune
homeostasis and preventing autoimmunity. Here, we review the components of T‐cell …