Monocytes originate from progenitors in the bone marrow and traffic via the bloodstream to
peripheral tissues. During both homeostasis and inflammation, circulating monocytes leave …

Neuroinflammation is the coordinated response of the central nervous system (CNS) to
threats to its integrity posed by a variety of conditions, including autoimmunity, pathogens …

Each year about 650,000 Europeans die from stroke and a similar number lives with the
sequelae of multiple sclerosis (MS). Stroke and MS differ in their etiology. Although cause …

We examine here several diseases that are associated with inappropriate activation of the
chemokine network. Detailed comment has been restricted to pathological states for which …

Millions of people worldwide suffer from neuropathic pain as a result of damage to or
dysfunction of the nervous system under various disease conditions. Development of …

This article provides a comprehensive overview of the pathology of multiple sclerosis (MS),
including recent insights into its molecular neuropathology and immunology. It shows that all …

The blood-brain barrier (BBB) is a complex organization of cerebral endothelial cells (C EC),
pericytes and their basal lamina, which are surrounded and supported by astrocytes and …

Chemokines direct tissue invasion by specific leukocyte populations. Thus, chemokines may
play a role in multiple sclerosis (MS), an idiopathic disorder in which the central nervous …

Multiple sclerosis (MS) is a T cell-dependent chronic inflammatory disease of the central
nervous system. The role of chemokines in MS and its different stages is uncertain. Recent …

Chemokines and their receptors have crucial roles in the trafficking of leukocytes, and are of
particular interest in the context of the unique immune responses elicited in the central …