[HTML][HTML] The human antibody response to influenza A virus infection and vaccination

F Krammer - Nature Reviews Immunology, 2019 - nature.com
The adaptive immune response to influenza virus infection is multifaceted and complex,
involving antibody and cellular responses at both systemic and mucosal levels. Immune …

From original antigenic sin to the universal influenza virus vaccine

C Henry, AKE Palm, F Krammer, PC Wilson - Trends in immunology, 2018 - cell.com
Antibody responses are essential for protection against influenza virus infection. Humans
are exposed to a multitude of influenza viruses throughout their lifetime and it is clear that …

An influenza H1 hemagglutinin stem-only immunogen elicits a broadly cross-reactive B cell response in humans

SF Andrews, LY Cominsky, GD Shimberg… - Science Translational …, 2023 - science.org
Current yearly seasonal influenza vaccines primarily induce an antibody response directed
against the immunodominant but continually diversifying hemagglutinin (HA) head region …

Broadly protective human antibodies that target the active site of influenza virus neuraminidase

D Stadlbauer, X Zhu, M McMahon, JS Turner… - Science, 2019 - science.org
Better vaccines against influenza virus are urgently needed to provide broader protection
against diverse strains, subtypes, and types. Such efforts are assisted by the identification of …

Heat-killed Lactobacillus casei confers broad protection against influenza A virus primary infection and develops heterosubtypic immunity against future secondary …

YJ Jung, YT Lee, VL Ngo, YH Cho, EJ Ko, SM Hong… - Scientific reports, 2017 - nature.com
Lactic acid bacteria (LAB) are the common probiotics. Here, we investigated the antiviral
protective effects of heat-killed LAB strain Lactobacillus casei DK128 (DK128) on influenza …

Evaluation of preexisting anti-hemagglutinin stalk antibody as a correlate of protection in a healthy volunteer challenge with influenza A/H1N1pdm virus

JK Park, A Han, L Czajkowski, S Reed, R Athota… - MBio, 2018 - Am Soc Microbiol
Influenza virus hemagglutinin (HA) surface glycoprotein is currently the primary target of
licensed influenza vaccines. Recently, broadly reactive antibodies that target the stalk region …

Prevention and treatment of respiratory viral infections: presentations on antivirals, traditional therapies and host-directed interventions at the 5th ISIRV Antiviral Group …

JL McKimm-Breschkin, S Jiang, DS Hui, JH Beigel… - Antiviral research, 2018 - Elsevier
Abstract The International Society for Influenza and other Respiratory Virus Diseases held its
5th Antiviral Group (isirv-AVG) Conference in Shanghai, China, in conjunction with the …

A single vaccine protects against SARS-CoV-2 and influenza virus in mice

K Cao, X Wang, H Peng, L Ding, X Wang, Y Hu… - Journal of …, 2022 - Am Soc Microbiol
The ongoing SARS-CoV-2 pandemic poses a severe global threat to public health, as do
influenza viruses and other coronaviruses. Here, we present chimpanzee adenovirus 68 …

Broad hemagglutinin-specific memory B cell expansion by seasonal influenza virus infection reflects early-life imprinting and adaptation to the infecting virus

BL Tesini, P Kanagaiah, J Wang, M Hahn… - Journal of …, 2019 - Am Soc Microbiol
Memory B cells (MBCs) are key determinants of the B cell response to influenza virus
infection and vaccination, but the effect of different forms of influenza antigen exposure on …

[HTML][HTML] Novel hemagglutinin nanoparticle influenza vaccine with Matrix-M™ adjuvant induces hemagglutination inhibition, neutralizing, and protective responses in …

G Smith, Y Liu, D Flyer, MJ Massare, B Zhou, N Patel… - Vaccine, 2017 - Elsevier
Influenza viruses frequently acquire mutations undergoing antigenic drift necessitating
annual evaluation of vaccine strains. Highly conserved epitopes have been identified in the …