Impact of protein kinase PKR in cell biology: from antiviral to antiproliferative action

MA Garcia, J Gil, I Ventoso, S Guerra… - Microbiology and …, 2006 - Am Soc Microbiol
The double-stranded RNA-dependent protein kinase PKR is a critical mediator of the
antiproliferative and antiviral effects exerted by interferons. Not only is PKR an effector …

ATF3 transcription factor and its emerging roles in immunity and cancer

MR Thompson, D Xu, BRG Williams - Journal of molecular medicine, 2009 - Springer
Abstract Activating transcription factor 3 (ATF3) is a member of the ATF/cyclic AMP response
element-binding (ATF/CREB) family of transcription factors. It is an adaptive-response gene …

Risk factors for ovarian cancer: an overview with emphasis on hormonal factors

F Salehi, L Dunfield, KP Phillips, D Krewski… - Journal of Toxicology …, 2008 - Taylor & Francis
Ovarian cancer is the fifth most frequently occurring cancer among women and leading
cause of gynecological cancer deaths in North America. Although the etiology of ovarian …

Incessant ovulation, inflammation and epithelial ovarian carcinogenesis: revisiting old hypotheses

JS Fleming, CR Beaugié, I Haviv… - Molecular and cellular …, 2006 - Elsevier
Epithelial ovarian cancer (EOC) is often a lethal disease because in many cases early
symptoms go undetected. Although research proceeds apace, as yet there are few reliable …

Channel-like functions of the 18-kDa translocator protein (TSPO): regulation of apoptosis and steroidogenesis as part of the host-defense response

L Veenman, V Papadopoulos… - Current pharmaceutical …, 2007 - ingentaconnect.com
Due to its channel-like properties, the peripheral-type benzodiazepine receptor (PBR) has
been renamed the translocator protein (TSPO). In eukaryotes, the TSPO is primarily located …

A potential dichotomous role of ATF3, an adaptive-response gene, in cancer development

X Yin, JW Dewille, T Hai - Oncogene, 2008 - nature.com
Abstract Activating transcription factor 3 (ATF3) is a member of the ATF/cyclic AMP response
element-binding family of transcription factors. We present evidence that ATF3 has a …

DLC‐1: a Rho GTPase‐activating protein and tumour suppressor

ME Durkin, BZ Yuan, X Zhou… - Journal of cellular …, 2007 - Wiley Online Library
• Introduction‐The deleted in liver cancer family of RhoGAP domain proteins‐DLC‐1‐DLC‐2‐
DLC‐3‐Invertebrate DLC‐1‐like proteins• Expression of DLC family proteins• Features of …

Activating transcription factor 3, a stress-inducible gene, suppresses Ras-stimulated tumorigenesis

D Lu, CD Wolfgang, T Hai - Journal of biological chemistry, 2006 - ASBMB
ATF3 is a stress-inducible gene that encodes a member of the ATF/CREB family of
transcription factors. Current literature indicates that ATF3 affects cell death and cell cycle …

Hormone response in ovarian cancer: time to reconsider as a clinical target?

F Modugno, R Laskey, AL Smith… - Endocrine-related …, 2012 - erc.bioscientifica.com
Ovarian cancer is the sixth most common cancer worldwide among women in developed
countries and the most lethal of all gynecologic malignancies. There is a critical need for the …

Caveolin‐1: an ambiguous partner in cell signalling and cancer

AFG Quest, JL Gutierrez‐Pajares… - Journal of cellular and …, 2008 - Wiley Online Library
• Introduction• The caveolins• Caveolin‐1 in cell physiology‐Caveolin‐1 distribution‐
Caveolin‐1 and internalization‐Caveolin‐1 and cholesterol‐Regulation of caveolin‐1 …