Biological activity of ionic liquids and their application in pharmaceutics and medicine

KS Egorova, EG Gordeev, VP Ananikov - Chemical reviews, 2017 - ACS Publications
Ionic liquids are remarkable chemical compounds, which find applications in many areas of
modern science. Because of their highly tunable nature and exceptional properties, ionic …

Do Ionic Liquids Exhibit the Required Characteristics to Dissolve, Extract, Stabilize, and Purify Proteins? Past-Present-Future Assessment

P Bharmoria, AA Tietze, D Mondal, TS Kang… - Chemical …, 2024 - ACS Publications
Proteins are highly labile molecules, thus requiring the presence of appropriate solvents and
excipients in their liquid milieu to keep their stability and biological activity. In this field, ionic …

Defeat undefeatable: Ionic liquids as novel antimicrobial agents

J Michalski, C Odrzygóźdź, P Mester, D Narożna… - Journal of Molecular …, 2023 - Elsevier
Emerging antimicrobial resistance and spread of drug-resistant pathogens is currently-one
of the biggest threats posed to global health. Due to that, search of new antimicrobials …

Controlling amyloid fibril properties via ionic liquids: The representative case of ethylammonium nitrate and tetramethylguanidinium acetate on the amyloidogenesis of …

VVS Pillai, P Kumari, S Kolagatla… - The Journal of …, 2022 - ACS Publications
Protein aggregation into amyloid fibrils has been observed in several pathological
conditions and exploited in nanotechnology. It is also key in several biochemical processes …

Cryopreservation of Proteins Using Ionic Liquids: A Case Study of Cytochrome c

T Takekiyo, Y Ishikawa… - The Journal of Physical …, 2017 - ACS Publications
Aqueous ionic liquid (IL) solutions form a glassy state at 77 K over a wide concentration of
ILs. They have potential as novel cryopreservation/refolding solvents for proteins. However …

Strategic planning of proteins in ionic liquids: future solvents for the enhanced stability of proteins against multiple stresses

A Kumar, K Bhakuni, P Venkatesu - Physical Chemistry Chemical …, 2019 - pubs.rsc.org
Ionic liquids (ILs) present a vast number of solvents capable of replacing toxic organic
solvents in chemical, biotechnology and biomedical applications. ILs are inexpensive and …

Tetrabutylammonium based ionic liquids (ILs) inhibit the amyloid aggregation of superoxide dismutase 1 (SOD1)

M Kumari, S Sharma, S Deep - Journal of Molecular Liquids, 2022 - Elsevier
Aggregation of a protein is associated with several biological and industrial processes:
some wanted and some unwanted. An understanding of the mechanism of modulation of …

Aromatic vs alicyclic: hydrophobicity of the ionic liquid on protein stability and fibril formation

P Kushwaha, NP Prabhu - Journal of Molecular Liquids, 2024 - Elsevier
Ionic liquids (ILs) are environment-friendly solvents with potential applications in
biochemical reactions and as pharmaceutical ingredients. They are used to stabilize …

Effect of 1-ethyl-3-methylimidazolium tetrafluoroborate and acetate ionic liquids on stability and amyloid aggregation of lysozyme

D Fedunova, A Antosova, J Marek, V Vanik… - International Journal of …, 2022 - mdpi.com
Amyloid fibrils draw attention as potential novel biomaterials due to their high stability,
strength, elasticity or resistance against degradation. Therefore, the controlled and fast …

Elucidation of the effect of some cholinium amino acid ionic liquids on the thermal and the conformational stability of insulin

M Guncheva, P Ossowicz, E Janus, S Todinova… - Journal of Molecular …, 2019 - Elsevier
The major concerns about protein-based drugs are their stability ie maintaining the protein
in the folded state throughout processing and storage, as well as the preparation of novel …