The endocannabinoid system: drug targets, lead compounds, and potential therapeutic applications

DM Lambert, CJ Fowler - Journal of medicinal chemistry, 2005 - ACS Publications
As far as can be ascertained from archeological sources, preparations of the hemp
Cannabis sativa L. were widely used by humans for either therapeutic or ritual purposes in …

Voltage gated ion channels: targets for anticonvulsant drugs

AC Errington, T Stohr, G Lees - Current topics in medicinal …, 2005 - ingentaconnect.com
Epilepsy is one of the most prevalent neurological syndromes in the world today. Epilepsy
describes a group of brain disorders whose symptoms and causes are diverse and …

The endocannabinoid system and rimonabant: a new drug with a novel mechanism of action involving cannabinoid CB1 receptor antagonism – or inverse agonism …

S Xie, MA Furjanic, JJ Ferrara… - Journal of clinical …, 2007 - Wiley Online Library
There is considerable evidence that the endocannabinoid (endogenous cannabinoid)
system plays a significant role in appetitive drive and associated behaviours. It is therefore …

Determination of the contents of the main biochemical compounds of Adlay (Coxi lachrymal-jobi)

TT Wu, AL Charles, TC Huang - Food chemistry, 2007 - Elsevier
Adlay (Coxi lachrymal-jobi), an annual crop, has long been used in traditional Chinese
medicine for its biological activity and as a nourishing food. Its phytochemical composition …

Differential proteomic analysis of the anti-depressive effects of oleamide in a rat chronic mild stress model of depression

L Ge, M Zhu, JY Yang, F Wang, R Zhang… - Pharmacology …, 2015 - Elsevier
Depression is a complex psychiatric disorder, and its etiology and pathophysiology are not
completely understood. Depression involves changes in many biogenic amine …

A cannabinoid receptor-mediated mechanism participates in the neuroprotective effects of oleamide against excitotoxic damage in rat brain synaptosomes and cortical …

M Maya-López, LC Rubio-López… - Neurotoxicity …, 2020 - Springer
A number of physiological responses in the central nervous system (CNS) are regulated by
the endocannabinoid system (ECS). Inhibition of neuronal excitability via activation of …

The slip agents oleamide and erucamide reduce biofouling by marine benthic organisms (diatoms, biofilms and abalones)

P Getachew, M Getachew, J Joo, YS Choi… - Toxicology and …, 2016 - Springer
Primary fatty acid amides are commonly found in grasses, microalgae, and animal.
Oleamide and erucamide are fatty acid amide derivatives of oleic and brassidic acids …

Garcinia oligantha: A comprehensive overview of ethnomedicine, phytochemistry and pharmacology

JQ Tan, L Zhang, HX Xu - Journal of Ethnopharmacology, 2023 - Elsevier
Abstract Ethnopharmacological relevance Garcinia oligantha Merr. is an ethnomedicine
plant mainly distributed in Guangdong and Hainan, China. It has the effects of heat-clearing …

Effects in vitro and in vivo of a gap junction blocker on epileptiform activities in a genetic model of absence epilepsy

S Gigout, J Louvel, R Pumain - Epilepsy research, 2006 - Elsevier
We investigated the effects of carbenoxolone (CBX), a gap junctions (GJ) blocker, on
epileptiform activities in vivo and in vitro. In a first series of experiments, ip CBX decreased …

Anxiolytic-like effects of oleamide in group-housed and socially isolated mice

XY Wei, JY Yang, YX Dong, CF Wu - Progress in Neuro …, 2007 - Elsevier
Oleamide (cis-9, 10-octadecenoamide) is an endogenous sleep-inducing lipid and
prototypic member of a new class of biological signaling molecules identified in recent …