The molecular basis of nutrient sensing and signalling by mTORC1 in metabolism regulation and disease
Abstract The Ser/Thr kinase mechanistic target of rapamycin (mTOR) is a central regulator of
cellular metabolism. As part of mTOR complex 1 (mTORC1), mTOR integrates signals such …
cellular metabolism. As part of mTOR complex 1 (mTORC1), mTOR integrates signals such …
Balancing lysosome abundance in health and disease
Lysosomes are catabolic organelles that govern numerous cellular processes, including
macromolecule degradation, nutrient signalling and ion homeostasis. Aberrant changes in …
macromolecule degradation, nutrient signalling and ion homeostasis. Aberrant changes in …
Induction of lysosomal and mitochondrial biogenesis by AMPK phosphorylation of FNIP1
N Malik, BI Ferreira, PE Hollstein, SD Curtis, E Trefts… - Science, 2023 - science.org
Cells respond to mitochondrial poisons with rapid activation of the adenosine
monophosphate–activated protein kinase (AMPK), causing acute metabolic changes …
monophosphate–activated protein kinase (AMPK), causing acute metabolic changes …
[HTML][HTML] Structure of the lysosomal mTORC1–TFEB–Rag–Ragulator megacomplex
The transcription factor TFEB is a master regulator of lysosomal biogenesis and autophagy.
The phosphorylation of TFEB by the mechanistic target of rapamycin complex 1 (mTORC1) …
The phosphorylation of TFEB by the mechanistic target of rapamycin complex 1 (mTORC1) …
Non-canonical mTORC1 signaling at the lysosome
G Napolitano, C Di Malta, A Ballabio - Trends in cell biology, 2022 - cell.com
The mechanistic target of rapamycin complex 1 (mTORC1) signaling hub integrates multiple
environmental cues to modulate cell growth and metabolism. Over the past decade …
environmental cues to modulate cell growth and metabolism. Over the past decade …
A Rag GTPase dimer code defines the regulation of mTORC1 by amino acids
P Gollwitzer, N Grützmacher, S Wilhelm, D Kümmel… - Nature cell …, 2022 - nature.com
Amino acid availability controls mTORC1 activity via a heterodimeric Rag GTPase complex
that functions as a scaffold at the lysosomal surface, bringing together mTORC1 with its …
that functions as a scaffold at the lysosomal surface, bringing together mTORC1 with its …
Fine-tuning cardiac insulin-like growth factor 1 receptor signaling to promote health and longevity
M Abdellatif, V Trummer-Herbst, AM Heberle… - Circulation, 2022 - Am Heart Assoc
Background: The insulin-like growth factor 1 (IGF1) pathway is a key regulator of cellular
metabolism and aging. Although its inhibition promotes longevity across species, the effect …
metabolism and aging. Although its inhibition promotes longevity across species, the effect …
TFE3-rearranged PEComa/PEComa-like neoplasms: report of 25 new cases expanding the clinicopathologic spectrum and highlighting its association with prior …
Since their original description as a distinctive neoplastic entity,~ 50 TFE3-rearranged
perivascular epithelioid cell tumors (PEComas) have been reported. We herein report 25 …
perivascular epithelioid cell tumors (PEComas) have been reported. We herein report 25 …
Nutrient-sensing mTORC1 and AMPK pathways in chronic kidney diseases
Nutrients such as glucose, amino acids and lipids are fundamental sources for the
maintenance of essential cellular processes and homeostasis in all organisms. The nutrient …
maintenance of essential cellular processes and homeostasis in all organisms. The nutrient …
Autophagy in cancer cell remodeling and quality control
GA Hernandez, RM Perera - Molecular cell, 2022 - cell.com
As one of the two highly conserved cellular degradation systems, autophagy plays a critical
role in regulation of protein, lipid, and organelle quality control and cellular homeostasis …
role in regulation of protein, lipid, and organelle quality control and cellular homeostasis …