Inflammasomes are critical sentinels of the innate immune system that respond to threats to
the host through recognition of distinct molecules, known as pathogen-or damage …

The COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2), results in life-threatening disease in a minority of patients, especially elderly …

Inflammasomes are important sentinels of innate immune defence, sensing pathogens and
inducing cell death in infected cells. There are several inflammasome sensors that each …

The mammalian NLR gene family was first reported over 20 years ago, although several
genes that were later grouped into the family were already known at that time. Although it is …

The process of pyroptosis is mediated by inflammasomes and a downstream effector known
as gasdermin D (GSDMD). Upon cleavage by inflammasome-associated caspases, the N …

Inflammasomes are cytoplasmic multiprotein complexes comprising a sensor protein,
inflammatory caspases, and in some but not all cases an adapter protein connecting the two …

Pyroptosis, apoptosis and necroptosis are the most genetically well-defined programmed
cell death (PCD) pathways, and they are intricately involved in both homeostasis and …

Abstract NLRP3 (NOD-, LRR-and pyrin domain-containing protein 3) is an intracellular
sensor that detects a broad range of microbial motifs, endogenous danger signals and …

Programmed cell death (PCD) refers to the way in which cells die depending on specific
genes encoding signals or activities. Apoptosis, autophagy, and pyroptosis are all …

Caspases are an evolutionary conserved family of cysteine proteases that are centrally
involved in cell death and inflammation responses. A wealth of foundational insight into the …