The determinant role of IL-6 in the establishment of inflammation leading to spontaneous preterm birth

E Prairie, F Cote, M Tsakpinoglou, M Mina… - Cytokine & growth factor …, 2021 - Elsevier
Preterm birth (PTB) and its consequences are a major public health concern as preterm
delivery is the main cause of mortality and morbidity at birth. There are many causes of PTB …

Recent advances in our understanding of NEC diagnosis, prognosis and surgical approach

GS Bethell, NJ Hall - Frontiers in Pediatrics, 2023 - frontiersin.org
Necrotising enterocolitis (NEC) remains a devasting condition that has seen limited
improvement in outcomes in recent years. The incidence of the disease is increasing as …

Surgical necrotizing enterocolitis: association between surgical indication, timing, and outcomes

GS Bethell, M Knight, NJ Hall - Journal of Pediatric Surgery, 2021 - Elsevier
Abstract Background/Purpose Despite improvements in neonatal care the outcomes of
Necrotizing Enterocolitis (NEC) remain unchanged over previous decades. The study aims …

Parthanatos initiated by ROS-induced DNA damage is involved in intestinal epithelial injury during necrotizing enterocolitis

L Xu, S Ma, M Qu, N Li, X Sun, T Wang, L Chen… - Cell Death …, 2024 - nature.com
Necrotizing enterocolitis (NEC) involves intestinal epithelial damage and inflammatory
response and is associated with high morbidity and mortality in infants. To improve …

A hydrogen-sulfide derivative of mesalamine reduces the severity of intestinal and lung injury in necrotizing enterocolitis through endothelial nitric oxide synthase

BD Hosfield, CE Hunter, H Li… - American Journal …, 2022 - journals.physiology.org
Necrotizing enterocolitis (NEC) remains a devastating disease that affects preterm infants.
Hydrogen sulfide (H2S) donors have been shown to reduce the severity of NEC, but the …

Correlation of systemic immune-inflammation Index with surgical necrotizing enterocolitis

W Feng, J Hou, C Xiang, X Die, J Sun, Z Guo… - Frontiers in …, 2022 - frontiersin.org
Background Systemic Immune-Inflammation Index (SII), known as an easy, economical and
useful marker, correlates with the severity of inflammatory response. However, the …

Association of neutrophil to lymphocyte ratio with preterm necrotizing enterocolitis: a retrospective case-control study

Y Mu, H Wang - BMC gastroenterology, 2022 - Springer
Background There have been few studies on the relationship between the neutrophil to
lymphocyte ratio (NLR) and necrotizing enterocolitis (NEC). We conducted a retrospective …

Methods of identifying surgical Necrotizing Enterocolitis—a systematic review and meta-analysis

GS Bethell, IH Jones, C Battersby, M Knight… - Pediatric Research, 2024 - nature.com
Background Current data suggests potential benefit of earlier surgery for necrotizing
enterocolitis (NEC) however this requires accurate prognostication early in the disease …

Red blood cell transfusions post diagnosis of necrotizing enterocolitis and the deterioration of necrotizing enterocolitis in full-term and near-term infants: a propensity …

L Luo, X Liu, H Yu, M Luo, W Jia, W Dong, X Lei - BMC pediatrics, 2022 - Springer
Background Necrotizing enterocolitis (NEC) is one of serious gastrointestinal inflammatory
diseases in newborn infants, with a high morbidity and mortality. Red blood cell transfusion …

Estrogen Alleviates Oxidative Bowel Injury and Neuroinflammation in Necrotizing Enterocolitis

KK Cerit, T Koyuncuoğlu, B Akcan, NS Çağatay… - Journal of Surgical …, 2025 - Elsevier
Introduction High mortality and morbidity of neonates with necrotizing enterocolitis (NEC)
necessitates the investigation of novel therapies to improve outcomes. It was aimed to …