Gastrulation is the process whereby cells exit pluripotency and concomitantly acquire and
pattern distinct cell fates. This is driven by the convergence of WNT, BMP, Nodal and FGF …

Micropatterning encompasses a set of methods aimed at precisely controlling the spatial
distribution of molecules onto the surface of materials. Biologists have borrowed the idea …

Local cell densities and positioning within cellular monolayers and stratified epithelia have
important implications for cell interactions and the functionality of various biological …

The mechanism by which morphogenetic signals engage the regulatory networks
responsible for early embryonic tissue patterning is incompletely understood. Here, we …

In vitro models of postimplantation human development are valuable to the fields of
regenerative medicine and developmental biology. Here, we report characterization of a …

During development, cell state transitions are coordinated through changes in the identity of
molecular regulators in a cell type‐and dose‐specific manner. The ability to rationally …

The increasing availability of single-cell RNA-sequencing (scRNA-seq) data from various
developmental systems provides the opportunity to infer gene regulatory networks (GRNs) …

Low differentiation propensity towards a targeted lineage can significantly hamper the utility
of individual human pluripotent stem cell (hPSC) lines in biomedical applications. Here, we …

A fundamental goal in biology is to understand how patterns emerge during development.
Several groups have shown that patterning can be achieved in vitro when stem cells are …

The emergence of the anterior-posterior body axis during early gastrulation constitutes a
symmetry-breaking event, which is key to the development of bilateral organisms, and its …