Pyrimidines are aromatic heterocyclic compounds that contain two nitrogen atoms at
positions 1 and 3 of the six-membered ring. Numerous natural and synthetic pyrimidines are …

Positron emission tomography (PET) is an important driver for present day healthcare.
Fluorine-18 is the most widely used radioisotope for PET imaging and a thorough overview …

Abstract Selective cyclooxygenase-2 (COX-2) inhibitors have exhibited notable medicinal
importance. In recent years, the discovery of new anti-inflammatory agents as selective COX …

Two series of cyanopyrimidine hybrids were synthesized bearing either benzo [d] imidazole,
benzo [d] oxazole, benzo [d] thiazole, and benzo [b] thiophene derivatives via methylene …

Abstract Background The P2X7 receptor has been shown to play a fundamental role in the
initiation and sustenance of the inflammatory cascade. The development of a novel fluorine …

Inflammation involves the activation of innate immune cells and is believed to play an
important role in the development and progression of both infectious and non-infectious …

Due to the biological importance of thienopyrimidine derivatives, we present here a synthetic
way for the design of new thienopyrimidines (2‒11) using the precursor 2-(4-Oxo-9-phenyl …

Highlights•Structural analysis of protein target complexes with NSAIDs is reported.•Atomic
details of the molecular interactions are described.•Target proteins are divided into three …

Abstract Background Cyclooxygenase-2 (COX-2) is the inducible isoform of the
cyclooxygenase enzyme family. COX-2 is involved in tumor development and progression …

A series of novel fluorine‐containing cyclooxygenase‐2 (COX‐2) inhibitors was designed
and synthesized based on the previously reported fluorescent COX‐2 imaging agent …