Neural plasticity, a fundamental mechanism of neuronal adaptation, is disrupted in
depression. The changes in neural plasticity induced by stress and other negative stimuli …

Depression is a common global mental disorder that seriously harms human physical and
mental health. With the development of society, the increase of pressure and the role of …

Stress is an adaptive response to environment aversive stimuli and a common life
experience of one's daily life. Chronic or excessive stress especially that happened in early …

Background High-fat diet (HFD) consumption is an important reason for promoting
depression, but the mechanism is unclear. The present study aims to explore the …

Affective disorders are a group of neuropsychiatric disorders characterized by severe mood
dysregulations accompanied by sleep, eating, cognitive, and attention disturbances, as well …

Suicide is a major public health concern. A significant proportion of depressed individuals
show suicidal ideation. The currently available medications are not optimal and a large …

The high incidence and relapse rate of depression, as well comorbidity with other diseases,
has made depression one of the primary causes of years of life lived with disability …

Multiple sclerosis (MS) is a chronic disease of the central nervous system that affects the
brain and spinal cord. There are several disease courses in MS including relapsing …

Abstract Background Lily Bulb and Rehmannia Decoction (LBRD), is a traditional Chinese
formula that has been shown to be safe and effective against depression; however, its …

Type 2 diabetes mellitus (T2DM) is closely related to depression; however, the exact
molecular mechnisms of this association are unknown. Here, we investigated whether …