Nicotinic acetylcholine, serotonin type 3, γ-amminobutyric acid type A, and glycine receptors
are major players of human neuronal communication. They belong to the family of …

Using the crosstalk between the nicotinic acetylcholine receptor (nAChR) and its lipid
microenvironment as a paradigm, this short overview analyzes the occurrence of structural …

Proteostasis maintenance of γ-aminobutyric acid type A (GABA A) receptors dictates their
function in controlling neuronal inhibition in mammalian central nervous systems. However …

Synaptic receptors respond to neurotransmitters by opening an ion channel across the post-
synaptic membrane to elicit a cellular response. Here we use recent Torpedo acetylcholine …

Structural rearrangements underlying functional transitions of pentameric ligand-gated ion
channels (pLGICs) are not fully understood. Using 19 F nuclear magnetic resonance and …

For decades, the development of selective compounds has been the main goal for chemists
and biologists involved in drug discovery. However, diverse lines of evidence indicate that …

GABA A receptors are the primary inhibitory ion channels in the mammalian central nervous
system. The A322D mutation in the α1 subunit results in its excessive endoplasmic reticulum …

Nicotinic acetylcholine receptors (nAChR) are ligand gated ion channels, identified as
therapeutic targets for a range of human diseases. Drug design for nAChR related disorders …

Introduction: Polypharmacology, which refers to the ability of a molecule to simultaneously
interact with multiple target proteins, is shifting the drug discovery process from a 'one-drug …

NMR spectroscopy is one of the major tools to provide atomic resolution protein structural
information. It has been used to elucidate the molecular details of interactions between …