Privileged structures have been widely used as an effective template in medicinal chemistry
for drug discovery. Chalcone is a common simple scaffold found in many naturally occurring …

The ability to control cell volume is pivotal for cell function. Cell volume perturbation elicits a
wide array of signaling events, leading to protective (eg, cytoskeletal rearrangement) and …

Acute-on-chronic liver failure (ACLF) is a complex syndrome that develops in patients with
cirrhosis and is characterized by acute decompensation, organ failure (s) and high short …

An effective host defense mechanism involves inflammation to eliminate pathogens from the
site of infection, followed by the resolution of inflammation and the restoration of tissue …

Natural or synthetic chalcones with different substituents have revealed a variety of
biological activities that may benefit human health. The underlying mechanisms of action …

Historically, anti-inflammatory drugs had their origins in the serendipitous discovery of
certain plants and their extracts being applied for the relief of pain, fever and inflammation …

Carcinogenesis encompasses 3 closely associated stages: initiation, progression, and
promotion. Phytochemicals are nonnutritive components of plants that are currently being …

The metabolism of arachidonic acid through lipoxygenase pathways leads to the generation
of various biologically active eicosanoids. The expression of these enzymes vary throughout …

The past decade has seen considerable interest and progress in unraveling the beneficial
health effects of tea, particularly its polyphenolic components and its antioxidant activity …

Herbs have been utilized to treat acute and chronic disorders for thousands of years. The
scientific basis for such utilization, however, has been poorly understood. Nonetheless, in …