Abstract The Janus kinases (JAKs) and signal transducer and activator of transcription
(STAT) proteins, particularly STAT3, are among the most promising new targets for cancer …

The Activator Protein-1 (AP-1) transcription factor (TF) family, composed of a variety of
members including c-JUN, c-FOS and ATF, is involved in mediating many biological …

Cholesterol is essential for cells to grow and proliferate. Normal mammalian cells meet their
need for cholesterol through its uptake or de novo synthesis, but the extent to which cancer …

Peripheral T cell lymphomas (PTCLs) are a heterogeneous group of orphan neoplasms.
Despite the introduction of anthracycline-based chemotherapy protocols, with or without …

Anaplastic large cell lymphomas (ALCLs) are CD30-positive T-cell non-Hodgkin lymphomas
broadly segregated into ALK-positive and ALK-negative types. Although ALK-positive …

Peripheral T-cell lymphoma (PTCL) is a rare and heterogeneous group of clinically
aggressive diseases associated with poor prognosis. Except for ALK+ anaplastic large-cell …

Many transformed lymphoma cells show immune-phenotypes resembling the corresponding
normal lymphocytes; thus, they provide a guide for proper diagnosis and present promising …

Anaplastic large cell lymphoma (ALCL) was first described in 1985 as a large-cell neoplasm
with anaplastic morphology immunostained by the Ki-1 antibody, which recognizes CD30. In …

Simple Summary The first report of breast implant-associated anaplastic large cell
lymphoma (BIA-ALCL) was in 1997. Although BIA-ALCL develops around breast implants, it …

Anaplastic large cell lymphoma (ALCL) is a heterogeneous disease of debateable origin
that, in children, is largely anaplastic lymphoma kinase (ALK) positive with aberrant ALK …