Radiotherapy (RT) is a cancer treatment that uses high doses of radiation to kill cancer cells
and shrink tumors. Although great success has been achieved on radiotherapy, there is still …

Simple Summary Metastasis, the process by which cancer cells escape primary tumor site
and colonize distant organs, is responsible for most cancer-related deaths. The tumor …

Inhibition of carbonic anhydrase (CA, EC 4.2. 1.1) was clinically exploited for decades, as
most modern diuretics were obtained considering as lead molecule acetazolamide, the …

HIF1α is a common component of pathways involved in the control of cellular metabolism
and has a role in regulating immune cell effector functions. Additionally, HIF1α is critical for …

Advances in the carbonic anhydrase (CA, EC 4.2. 1.1) research over the last three decades
are presented, with an emphasis on the deciphering of the activation mechanism, the …

Six genetic families of the enzyme carbonic anhydrase (CA, EC 4.2. 1.1) were described to
date. Inhibition of CAs has pharmacologic applications in the field of antiglaucoma …

During the past three decades, mice, zebrafish, fruit flies, and Caenorhabditis elegans have
been the primary model organisms used for the study of various biological phenomena …

Introduction: The enzyme carbonic anhydrase (CA, EC 4.2. 1.1) is found in numerous
organisms across the tree of life, with seven distinct classes known to date. CA inhibition can …

The tumor microenvironment is crucial for the growth of cancer cells, triggering particular
biochemical and physiological changes, which frequently influence the outcome of …

Cancer is a dreadful disease with a high mortality rate, and it has become more and more
prevalent worldwide. Early diagnosis, prognosis and treatment monitoring with robust and …